AI Article Synopsis
- * The study confirmed known associations with the IL12A and IL12RB genes.
- * A combined analysis with Canadian data identified new risk loci at SPIB, IRF5-TNPO3, and 17q12-21, showing significant statistical associations and odds ratios indicating increased risk.
Article Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150510 | PMC |
| http://dx.doi.org/10.1038/ng.627 | DOI Listing |
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