Several infections in adults warrant special consideration in pregnant women given the potential fetal consequences. Among these are toxoplasmosis, parvovirus B19, and cytomegalovirus. These infections have an important effect on the developing fetus depending on the timing of infection. This article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. In addition, recommended testing, fetal surveillance, and treatment where indicated are outlined.
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Molecular Biology for Diagnosis of Congenital and Neonatal Infections in the Cerebrospinal Fluid of Newborns from a Brazilian Tertiary Hospital.
Microorganisms
October 2024
Department of Pediatrics, School of Medical Sciences, FCM Unicamp, Campinas 13083-970, SP, Brazil.
Unlabelled: The risk of infection transmission from mother to fetus depends on the pathogen. TORCH agents cause some neuroinfections, including Toxoplasmosis, rubella, Cytomegalovirus, herpes simplex 1 and 2, and others (Varicella Zoster, Parvovirus B-19, Epstein-Barr virus, and Zika virus). The consequences can be stillbirth, prematurity, uterine growth restriction, and congenital malformations.
View Article and Find Full Text PDFSystematic review on molecular detection of congenital and neonatal infections caused by TORCH and SARS-CoV-2 in newborns' cerebrospinal fluid.
Rev Paul Pediatr
September 2024
Universidade Estadual de Campinas, Campinas, SP, Brazil.
Article Synopsis
- The objective of the review was to verify the advantages of using molecular methods, specifically PCR, for diagnosing congenital infections in the cerebrospinal fluid of newborns.
- The literature search was thorough, utilizing multiple databases and adhering to systematic review guidelines to identify relevant studies published in several languages from August 2021 to December 2022.
- The findings suggest that molecular methods are effective for detecting pathogen genomes, particularly herpes simplex, in newborns suspected of having congenital neuroinfections based on nonspecific initial symptoms.
Seroprevalence and age-related susceptibility of TORCH infections in childbearing age women: A 5-year cross-sectional retrospective study and a literature review.
J Infect Public Health
October 2024
Unit of Clinical Microbiology, Department of Health Sciences, "Magna Græcia" University Hospital, 88100 Catanzaro, Italy.
Background: Serodiagnosis of TORCH infections should be performed in pre-pregnancy and reproductive-age women to prevent vertical transmission. Herein, we conducted a 5-year cross-sectional retrospective study in childbearing age women to provide prevalence data. Also, stratifying the cohort into three age groups, we identified those most susceptible to acute TORCH infections.
View Article and Find Full Text PDFSeroinfection of Antibodies to , Parvovirus B19, , and HIV in a Pregnant Attending a Medical Center in Northern Peru.
Infect Dis Obstet Gynecol
June 2024
Universidad San Ignacio de Loyola, Lima, Peru.
Introduction: Transplacental infections are frequent, especially in developing countries, where limited screening is performed to find infectious agents in the pregnant population. We aim to determine the clinical and epidemiological characteristics and seroinfection of antibodies against , parvovirus B19, , and HIV in pregnant women who attended the Motupe Health Center in Lambayeque, Peru during July-August 2018.
Methods: A descriptive cross-sectional study was conducted in 179 pregnant women interviewed with a standardized questionnaire.
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