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Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative.
J Infect Dis
October 2024
Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania.
Recent evidence challenges the belief that individuals who are Duffy-negative are resistant to Plasmodium vivax due to lacking the Duffy antigen receptor for chemokines. Erythrocyte-binding protein (EBP/DBP2) has shown moderate binding to Duffy-negative erythrocytes in vitro. Reticulocyte-binding protein 2b (RBP2b) interactions with transferrin receptor 1 suggest involvement in Duffy-negative infections.
View Article and Find Full Text PDFDetection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients.
Malar J
June 2024
School of Medical Laboratory Sciences, Faculty of Health Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of the disease with a steadily rising incidence. Conventional diagnostic methods, such as microscopy, have become less effective due to low parasite density, particularly among Duffy-negative human populations in Africa.
View Article and Find Full Text PDFPrevalence and Characteristics of Plasmodium vivax Gametocytes in Duffy-Positive and Duffy-Negative Populations across Ethiopia.
Am J Trop Med Hyg
June 2024
Department of Biological Sciences, University of North Carolina at Charlotte, North Carolina.
Plasmodium parasites replicate asexually in human hosts. The proportion of infections that carries gametocytes is a proxy for human-to-mosquito transmissibility. It is unclear which proportion of Plasmodium vivax infections in Duffy-negative populations carries gametocytes.
View Article and Find Full Text PDFEpidemiology of Plasmodium vivax in Duffy negatives and Duffy positives from community and health centre collections in Ethiopia.
Malar J
March 2024
Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California Irvine, Irvine, CA, 92697, USA.
Background: Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases in 2021 and 61% of the population living in areas at risk of malaria transmission. Throughout the country Plasmodium vivax and Plasmodium falciparum are co-endemic, and Duffy expression is highly heterogeneous.
View Article and Find Full Text PDFPrevalence and characteristics of Gametocytes in Duffy-positive and Duffy-negative populations across Ethiopia.
medRxiv
December 2023
Department of Biological Sciences, University of North Carolina at Charlotte, North Carolina, USA.
Article Synopsis
- Parasites replicate asexually in humans, and the presence of gametocytes in infections serves as an indicator for their potential transmission to mosquitoes.
- The study focuses on the prevalence of gametocytes in Duffy-negative individuals in Ethiopia, analyzing blood samples through microscopic and molecular methods.
- Results show that while gametocytes are present in both Duffy-negative and Duffy-positive individuals, a notable portion of Duffy-negative samples carry gametocytes, suggesting they may still play a role in malaria transmission.
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