Here we address two recent commentaries on our finding of an anticipatory trial-related signal that could not be predicted by concurrent electrode recordings. In addition, we offer a broad discussion regarding what our findings do and do not say about local neural activity underlying imaging signals.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677757 | PMC |
| http://dx.doi.org/10.1016/j.neuroimage.2010.07.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Timing and location of speech errors induced by direct cortical stimulation.
Brain Commun
March 2024
Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.
Cortical regions supporting speech production are commonly established using neuroimaging techniques in both research and clinical settings. However, for neurosurgical purposes, structural function is routinely mapped peri-operatively using direct electrocortical stimulation. While this method is the gold standard for identification of eloquent cortical regions to preserve in neurosurgical patients, there is lack of specificity of the actual underlying cognitive processes being interrupted.
View Article and Find Full Text PDFNew clinical trial design in precision medicine: discovery, development and direction.
Signal Transduct Target Ther
March 2024
Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to the underestimation of the significant heterogeneity across participants in traditional "one-size-fits-all" trials, patient-centered trials that could provide optimal therapy customization to individuals with specific biomarkers were developed including the basket, umbrella, and platform trial designs under the master protocol framework. In recent years, the successive FDA approval of indications based on biomarker-guided master protocol designs has demonstrated that these new clinical trials are ushering in tremendous opportunities.
View Article and Find Full Text PDFTiming and location of speech errors induced by direct cortical stimulation.
bioRxiv
January 2024
Department of Neurology, New York University School of Medicine, 550 1st Ave., New York, NY, 10016, USA.
Cortical regions supporting speech production are commonly established using neuroimaging techniques in both research and clinical settings. However, for neurosurgical purposes, structural function is routinely mapped peri-operatively using direct electrocortical stimulation. While this method is the gold standard for identification of eloquent cortical regions to preserve in neurosurgical patients, there is lack of specificity of the actual underlying cognitive processes being interrupted.
View Article and Find Full Text PDFSelection and Prejudice: Addressing Clinical Trial Disparities With a Review of Current Shortcomings and Future Directions.
Semin Radiat Oncol
October 2023
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.. Electronic address:
Growing evidence has demonstrated significant, persistent, and widespread disparities in cancer clinical trial enrollment across myriad disease sites and target populations. Although mechanisms underlying such disparities are complex and multifactorial, clinical trial eligibility criteria may serve as a key structural barrier to equitable and diverse trial enrollment. In this review, we provide an overview of the data describing historical and current disparities in cancer clinical trial enrollment and subsequently describe several patient-, institution-, and trial-related factors which appear to be key drivers of enrollment inequity, with specific discussion regarding the impact of eligibility criteria.
View Article and Find Full Text PDFConfirmation bias and vaccine-related beliefs in the time of COVID-19.
J Public Health (Oxf)
June 2023
Department of Psychology, University of Warwick, Coventry CV4 7AL, UK.
Background: In recent history mass vaccination has proved essential to dealing with pandemics. However, the effectiveness of a vaccine depends on the number of people willing to take it. One approach to encouraging uptake is to publish information about safety and effectiveness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!