AI Article Synopsis
- Chemokines and their receptors are involved in inflammation and tissue damage in autoimmune disorders like multiple sclerosis (MS), which causes myelin damage and neurological issues.
- Monocyte chemoattractant protein-1 (MCP-1) interacts with CCR2, affecting leukocyte migration into the central nervous system and promoting MS's T cell-mediated effects.
- A study of genomic DNA from 58 MS patients and 72 healthy controls found that the MCP-1 -2518G and CCR2 64Ile variants do not increase MS risk in Tunisians.
Article Abstract
Chemokines and their receptors are known to mediate inflammation and tissue damage in autoimmune disorders such as multiple sclerosis (MS). Multiple sclerosis is an inflammatory disease of the central nervous system, characterized by myelin damage and neurological complications. Monocyte chemoattractant protein-1 (MCP-1) interacts with the C-C chemokine receptor 2 (CCR2) and plays a role in the migration of leukocytes into the central nervous system, thus contributing to the T cell-mediated pathogenesis of MS. Genomic DNA obtained from 58 MS patients and 72 healthy controls was tested for the MCP-1 -2518 A>G and CCR2 Val64Ile polymorphisms using polymerase chain reaction-restriction fragment length polymorphism analysis. Neither the MCP-1 -2518G (p=0.43) nor the CCR2 64Ile (p=0.52) variant contributed to the risk of MS in Tunisians.
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| http://dx.doi.org/10.1016/j.jocn.2010.03.022 | DOI Listing |
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