The ability to control the size, shape, and material of a surface has reinvigorated the field of surface-enhanced Raman spectroscopy (SERS). Because excitation of the localized surface plasmon resonance of a nanostructured surface or nanoparticle lies at the heart of SERS, the ability to reliably control the surface characteristics has taken SERS from an interesting surface phenomenon to a rapidly developing analytical tool. This article first explains many fundamental features of SERS and then describes the use of nanosphere lithography for the fabrication of highly reproducible and robust SERS substrates. In particular, we review metal film over nanosphere surfaces as excellent candidates for several experiments that were once impossible with more primitive SERS substrates (e.g., metal island films). The article also describes progress in applying SERS to the detection of chemical warfare agents and several biological molecules.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1146/annurev.anchem.1.031207.112814 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
From automated Raman to cost-effective nanoparticle-on-film (NPoF) SERS spectroscopy: A combined approach for assessing micro- and nanoplastics released into the oral cavity from chewing gum.
J Hazard Mater
December 2024
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom; Material and Advanced Technologies for Healthcare, Queen's University of Belfast, 18-30 Malone Road, Belfast BT9 5DL, United Kingdom. Electronic address:
Microplastics (MPs) and Nanoplastics (NPs), a burgeoning health hazard, often go unnoticed due to suboptimal analytical tools, making their way inside our bodies through various means. Surface Enhanced Raman Spectroscopy (SERS), although is utilized in detecting NPs, challenges arise at low concentrations due to their low Raman cross section and inability to situate within hotspots owing to their ubiquitous size and shape. This study presents an innovative and cost-effective approach employing household metallic foils (aluminium and copper) as nanoparticle-on-film (NPoF) substrates for targeting such analytes.
View Article and Find Full Text PDFExtraordinary SERS on nanostructured self-assembled silver films due to preliminary random nano-profiling of substrate and ultrasonic exposure of analyte during the deposition.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Institute for Theoretical and Applied Electromagnetics RAS, Moscow 125412, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region 141700, Russia.
In this study, we have investigated the surface-enhanced Raman scattering (SERS) spectra of myoglobin on silver substrates with different morphology. The aim was to determine the optimal parameters of analyte and substrate preparation for obtaining of high-amplitude SERS spectra of proteins. It is shown that not only the morphology of the silver film, but also the method of analyte molecules deposition on the SERS substrate plays an important role.
View Article and Find Full Text PDFMultifunctional SERS Chip for Biological Application Realized by Double Fano Resonance.
Nanomaterials (Basel)
December 2024
Guangdong Provincial Key Laboratory of Photonics Information Technology, Guangdong University of Technology, Guangzhou 510006, China.
The in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal enhancement in recent years. However, biological cells are often immersed in different formulations of culture medium with varying refractive indexes and are highly sensitive to the temperature of the microenvironment.
View Article and Find Full Text PDFActive Surface-Enhanced Raman Scattering Platform Based on a 2D Material-Flexible Nanotip Array.
Biosensors (Basel)
December 2024
Department of Physics and Quantum Photonics Institute, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Two-dimensional materials with a nanostructure have been introduced as promising candidates for SERS platforms for sensing application. However, the dynamic control and tuning of SERS remains a long-standing problem. Here, we demonstrated active tuning of the enhancement factor of the first- and second-order Raman mode of monolayer (1L) MoS transferred onto a flexible metallic nanotip array.
View Article and Find Full Text PDFSelf-Assembled Lubricin (PRG-4)-Based Biomimetic Surface-Enhanced Raman Scattering Sensor for Direct Droplet Detection of Melamine in Undiluted Milk.
Biosensors (Basel)
December 2024
Department of Biochemistry and Chemistry, La Trobe University, Bundoora, VIC 3086, Australia.
Surface-enhanced Raman scattering (SERS) is a powerful optical sensing platform that amplifies the target signals by Raman scattering. Despite SERS enabling a meager detection limit, even at the single-molecule level, SERS also tends to equally enhance unwanted molecules due to the non-specific binding of noise molecules in clinical samples, which complicates its use in complex samples such as bodily fluids, environmental water, or food matrices. To address this, we developed a novel non-fouling biomimetic SERS sensor by self-assembling an anti-adhesive, anti-fouling, and size-selective Lubricin (LUB) coating on gold nanoparticle (AuNP) functionalized glass slide surfaces via a simple drop-casting method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!