AI Article Synopsis
- The study tests how Sanyak (Dioscoreae rhizome) affects the recovery of the sciatic nerve in rats after a crush injury.
- Sanyak extract applied at the injury site boosts the levels of certain proteins (GAP-43 and Cdc2) important for nerve regeneration.
- Results indicate that Sanyak not only enhances axon growth but also increases non-neuronal cell numbers, suggesting it promotes healing in damaged peripheral nerves.
Article Abstract
The present study evaluates the potential effects of Sanyak (Dioscoreae rhizome) on the regenerative capacity of the peripheral sciatic nerve after crush injury in rats. Focal application of Sanyak extract at the injury site increased GAP-43 and Cdc2 protein levels in the distal portion of the injured nerve. Immunohistochemical analysis showed that the signals of phospho-vimentin as Cdc2 substrate protein were almost colocalized with Cdc2. Retrograde DiI-tracing revealed enhancement in distal elongation of regenerating axons. Furthermore, the number of non-neuronal cells was higher in Sanyak-treated animals than saline controls. Thus, these data suggest that Sanyak extract is effective for promoting regenerative responses in injured peripheral neurons.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S2005-2901(09)60059-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration.
Korean J Physiol Pharmacol
September 2024
Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning, China.
Improving liver regeneration (LR) remains a medical issue, and there is currently a lack of safe and effective drugs for LR. Rhizoma Dioscoreae (SanYak, SY) is a traditional Chinese medicine. However, the underlying action mechanism of SY treatment for LR is yet to be fully elucidated.
View Article and Find Full Text PDFEffects of Dioscoreae Rhizoma (SanYak) on Peripheral Neuropathy and its Safety.
J Pharmacopuncture
September 2013
Department of Acupuncture & Moxibustion, Oriental Hospital of Daejeon University, Daejeon, Korea.
Objectives: This study aimed to evaluate the evidence available in the literature for the safety and efficacy of Dioscoreae Rhizoma(DR) for the treatment of peripheral neuropathy.
Methods: Literature searches were performed in MEDLINE and three Korean medical databases up to April 2013. All studies evaluating the effects on peripheral neuropathy or the safety of DR monopreparations were considered.
Evaluation of the safety of Sanyak (Dioscoreae rhizoma) pharmacopuncture according to the extraction method: a double-blind randomized controlled trial.
J Acupunct Meridian Stud
February 2013
Department of Oriental Medicine, Daejeon University, Daejeon, Republic of Korea.
Article Synopsis
- The study evaluated the safety of Sanyak (Dioscoreae rhizoma) pharmacopuncture in healthy participants.
- Pain after injection was notably significant in those who received the alcohol extract of Sanyak.
- Despite some changes in blood tests and liver function metrics post-injection, all results remained within normal limits, suggesting that Sanyak pharmacopuncture is safe with no severe adverse effects.
Clinical research of the efficacy and the safety of dioscoreae rhizoma (sanyak) pharmacopuncture therapy for peripheral facial paralysis patients.
J Pharmacopuncture
December 2012
Department of Acupuncture & Moxibustion, Oriental Hospital of Daejeon University, Daejeon, Korea.
Article Synopsis
- The study evaluates the effectiveness and safety of Sanyak pharmacopuncture therapy in treating patients with peripheral facial paralysis.
- It involved 70 hospitalized patients who received different types of pharmacopuncture therapies alongside acupuncture, showing significant improvements in facial paralysis symptoms for most groups.
- The findings suggest that Sanyak pharmacopuncture is generally safe, with minimal adverse effects, indicating potential for effective Oriental medical treatment in this condition.
Growth-promoting activity of Sanyak (Dioscoreae rhizoma) extract on injured sciatic nerve in rats.
J Acupunct Meridian Stud
September 2009
Department of Oriental Medicine, Daejeon University, Daejeon, Korea.
Article Synopsis
- The study tests how Sanyak (Dioscoreae rhizome) affects the recovery of the sciatic nerve in rats after a crush injury.
- Sanyak extract applied at the injury site boosts the levels of certain proteins (GAP-43 and Cdc2) important for nerve regeneration.
- Results indicate that Sanyak not only enhances axon growth but also increases non-neuronal cell numbers, suggesting it promotes healing in damaged peripheral nerves.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!