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Photon mini-GRID therapy for preoperative breast cancer tumor treatment: A treatment plan study.
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Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, France.
Background: Breast cancer is the leading cause of female cancer mortality worldwide, accounting for 1 in 6 cancer deaths. Surgery, radiation, and systemic therapy are the three pillars of breast cancer treatment, with several strategies developed to combine them. The association of preoperative radiotherapy with immunotherapy may improve breast cancer tumor control by exploiting the tumor radio-induced immune priming.
View Article and Find Full Text PDFEvaluating the biological impact of shelters on astronaut health during different solar particle events: a Geant4-DNA simulation study.
Radiat Environ Biophys
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Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.
Mechanistic Monte Carlo simulations have proven invaluable in tackling complex challenges in radiobiology, for example for protecting astronauts from solar particle events (SPEs) during deep space missions which remains an underexplored area. In this study, the Geant4-DNA Monte Carlo code was used to assess the DNA damage caused by SPEs and evaluate the protective effectiveness of a multilayer shelter. By examining the February 1956 and October 1989 SPEs-two extreme cases-the results showed that the proposed shelter reduced DNA damage by up to 57.
View Article and Find Full Text PDFThe concentration of malachite green in fish: a systematic review, meta-analysis, and probabilistic risk assessment.
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Faculty of Biotechnologies (BioTech), ITMO University, Saint Petersburg, Russia.
Malachite Green (MG) is an antibiotic with antifungal activity, which is illegal to use in agriculture due to its mutagenic and teratogenic properties. Several scientific papers have been published on MG in fish. Therefore, an attempt was made to determine the meta-analysis concentration of MG in fish based on countries and types of fish subgroups, as well as the health risks of consumers, using the Monte Carlo simulation (MCS) model.
View Article and Find Full Text PDFPrognostics of the knee osteoarthritis induced by cyclic loading activities. A model-based analysis.
Comput Methods Biomech Biomed Engin
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College of Engineering and Technology, American University of the Middle East, Egaila, Kuwait.
Repetitive mechanical stresses on the knee joint during daily activities accumulate fatigue damage in the articular cartilage (AC), leading to wear and knee osteoarthritis (KOA). Effective treatments remain limited, underscoring the need for predictive approaches to identify KOA early. This study proposes a mathematical model to estimate AC degradation under cyclic loading from walking.
View Article and Find Full Text PDFDeep learning-based Monte Carlo dose prediction for heavy-ion online adaptive radiotherapy and fast quality assurance: A feasibility study.
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Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Background: Online adaptive radiotherapy (OART) and rapid quality assurance (QA) are essential for effective heavy ion therapy (HIT). However, there is a shortage of deep learning (DL) models and workflows for predicting Monte Carlo (MC) doses in such treatments.
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