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Wood membrane: A sustainable electrochemical platform for enzyme-free and pretreatment-free monitoring uric acid in bodily fluids.
Anal Chim Acta
January 2025
School of Forensic Medicine, China Medical University, No.77 Puhe Road, Shenyang, Liaoning, 110122, China. Electronic address:
The detection of biomarkers is crucial for assessing disease status and progression. Uric acid (UA), a common biomarker in body fluids, plays an important role in the diagnosis and monitoring of conditions such as hyperuricemia, chronic kidney disease, and cardiovascular disease. However, the low concentration of UA in non-invasive body fluids, combined with numerous interfering substances, makes its detection challenging.
View Article and Find Full Text PDF[Interventional studies on acute-on-chronic liver failure: challenges and opportunities].
Zhonghua Gan Zang Bing Za Zhi
December 2024
Fourth Department of Liver Disease, Beijing Youan Hospital, Beijing100069, China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing100069, China.
Acute-on-chronic liver failure (ACLF) is a kind of complex syndrome characterized by acute deterioration of liver function on the basis of chronic liver disease, accompanied by organ failure and a high mortality rate. The International Society for Hepatology has proposed different definitions, diagnostic criteria, and treatment guidelines, which have led to differences in the clinical management of ACLF and underestimated the burden of the disease. Currently, there is no specific treatment for ACLF, and the overall prognosis is still not ideal.
View Article and Find Full Text PDF[Progress and prospects on liver support therapy for liver failure].
Zhonghua Gan Zang Bing Za Zhi
December 2024
Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou510515, China Department of Hepatology, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou511300, China.
Recently, organ support therapy for liver failure has made rapid progress in the direction of clearing bile acids, blood ammonia, and inflammatory factors. However, there is still a lack of high-level evidence-based medicine, necessitating extensive research on the pathogenesis of major subtypes of liver failure so as to explore collaborative key points of clinical research design decisions for appropriate organ support therapy.
View Article and Find Full Text PDFComputational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome.
J Pathol
February 2025
Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.
Colorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our understanding, it is critical that the TME is studied systematically within clinically annotated patient cohorts with long-term follow-up.
View Article and Find Full Text PDFLongitudinal Twin Growth Discordance Patterns and Adverse Perinatal Outcomes.
Am J Obstet Gynecol
January 2025
Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, United Kingdom; Twin and Multiple Pregnancy Centre for Research and Clinical Excellence, St George's University Hospital, St George's University of London, London, UK; Fetal Medicine Unit, Liverpool Women's Hospital, Liverpool, United Kingdom. Electronic address:
Objective: The objective of this study was to conduct a longitudinal assessment of inter-twin growth and Doppler discordance, to identify possible distinct patterns, and to investigate the predictive value of longitudinal discordance patterns for adverse perinatal outcomes in twin pregnancies.
Methods: This retrospective cohort study included twin pregnancies followed and delivered at a tertiary University Hospital in London (UK), between 2010 and 2023. We included pregnancies with at least three ultrasound assessments after 18 weeks and delivery after 34 weeks' gestation.
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