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Lysyl Oxidase Mediates Proliferation and Differentiation in the Esophageal Epithelium.
Biomolecules
December 2024
Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
In homeostatic conditions, the basal progenitor cells of the esophagus differentiate into a stratified squamous epithelium. However, in the setting of acid exposure or inflammation, there is a marked failure of basal cell differentiation, leading to basal cell hyperplasia. We have previously shown that lysyl oxidase (LOX), a collagen crosslinking enzyme, is upregulated in the setting of allergic inflammation of the esophagus; however, its role beyond collagen crosslinking is unknown.
View Article and Find Full Text PDFIdentification of G protein subunit alpha i3 as a promising oncotarget of LUAD.
Cell Signal
December 2024
Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:
Exploring new oncotargets essential for lung adenocarcinoma (LUAD) cell growth is important. Here the bioinformatical studies revealed that Gαi3 expression is elevated in LUAD tissues and its overexpression correlates with poor survival of the patients. Moreover, overexpression of Gαi3 mRNA and protein was detected in LUAD tissues of patients as well as in primary/immortalized LUAD cells.
View Article and Find Full Text PDFRegenerative characteristics of the immortal jellyfish, Turritopsis dohrnii, and their potential implications for human aging.
Rev Esp Geriatr Gerontol
December 2024
Department of Geriatrics, Aging Institute, Pontificia Universidad Javeriana, Bogotá, Colombia.
The jellyfish Turritopsis dohrnii (T. Nutricala) is a cnidarian of the Oceaniidae family that lives in the Mediterranean Sea. It is known as the immortal jellyfish since, through a process of cell development called transdifferentiation, it manages to return to a polyp state.
View Article and Find Full Text PDFGene expression profiles in human dental pulp stem cells treated short-term with lipopolysaccharides before and after osteoinduction.
J Oral Biosci
December 2024
Division of Physiology, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.
Objectives: Dental pulp stem cells (DPSCs) are essential for reparative dentinogenesis following damage or infection. DPSCs surrounding the blood vessels in the central region of the dental pulp actively proliferate after tooth injury and differentiate into new odontoblast-like cells or odontoblasts to form reparative dentin. However, the signaling pathways involved in undifferentiated and osteodifferentiated DPSCs under inflammatory conditions remain unclear.
View Article and Find Full Text PDFEffect of Long-Term Cisplatin Exposure on the Proliferative Potential of Immortalized Renal Progenitor Cells.
Int J Mol Sci
November 2024
Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Stop 9037, Grand Forks, ND 58203, USA.
Cisplatin (CisPt) is a widely used chemotherapeutic agent. However, its nephrotoxic effects pose significant risks, particularly for the development of acute kidney injury (AKI) and potential progression to chronic kidney disease (CKD). The present study investigates the impact of non-lethal exposure of CisPt to immortalized human renal epithelial precursor TERT cells (HRTPT cells) that co-express PROM1 and CD24, markers characteristic of renal progenitor cells.
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