Resistance to the toxic effects of reactive oxygen species produced by phagocytes and production of hydrolytic enzymes are important aspects of Candida albicans virulence. In this report, we compared twelve C. albicans isolates for their in vitro capacity to resist oxidants-hydrogen peroxide, menadione and paraquat; and to produce hydrolytic enzymes-phospholipase and protease. Different C. albicans isolates showed different degrees of resistance to oxidants as well as differences in production of hydrolytic enzymes. Resistance to oxidative stress did not correlate with production of hydrolytic enzymes. This reinforces the view that C. albicans differentially regulates the expression of virulence factors in response to local environmental conditions.
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http://dx.doi.org/10.1007/s11046-010-9346-x | DOI Listing |
Pharmaceutics
November 2024
Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10 000 Zagreb, Croatia.
Nabumetone (NAB) is a poorly soluble nonsteroidal anti-inflammatory prodrug (BCS class II drug) whose solubility is significantly improved by complexation with cyclodextrins (CDs). : The solid complexes, in a 1:1 molar ratio, were prepared by mechanochemical activation by grinding, using β-cyclodextrin (β-CD) and its derivatives, hydroxypropyl- and sulfobutylether-β-cyclodextrin (HP-β-CD and SBE-β-CD). The complexation was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and attenuated total reflectance Fourier-transformed infrared spectroscopy (ATR-FTIR).
View Article and Find Full Text PDFMicroorganisms
December 2024
Chaire de Recherche en Salubrité des Viandes (CRSV), Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
Avian necrotic enteritis due to the Gram-positive bacterium has re-emerged following the ban on antibiotic growth promoters in many poultry producing countries. The limited number of previous studies has left important gaps in our understanding of the genetic diversity and virulence traits of the pathogen. To address these knowledge gaps, in this study, we sequenced the genomes of 41 isolates recovered from commercial broiler chicken flocks in Quebec, Canada, including isolates from healthy birds and those affected by necrotic enteritis.
View Article and Find Full Text PDFMolecules
December 2024
Key Laboratory of Advanced Materials of Ministry of Education of China, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Waterborne polyurethane, with a mechanical strength comparable to solvent-based types, is eco-friendly and safe, using water as a dispersion medium. Polyacrylate excels in film formation and weather resistance but suffers from "hot stickiness and cold brittleness". Merging polyurethane and polyacrylate creates advanced hybrids, while organosilicon enhances properties but is restricted due to hydrolytic crosslinking.
View Article and Find Full Text PDFFoods
December 2024
Research Group on Biomass Energy, Department of Nuclear Energy, Federal University of Pernambuco, Recife 50740-545, PE, Brazil.
Food waste (FW) is a common source of contamination, contaminating both soils and water bodies by releasing greenhouse gases. FW holds great potential for biofuel and bioproduct production, which can mitigate its environmental impact and become a valuable addition to the circular bioeconomy. Therefore, this work aimed to investigate the use of food waste as a substrate to produce fermentable sugars and bioethanol.
View Article and Find Full Text PDFBiomolecules
November 2024
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
Banana crop ranks among the most crucial fruit and food crops in tropical and subtropical areas. Despite advancements in production technology, diseases such as cordana leaf spot, caused by , remain a significant challenge, reducing productivity and quality. Traditional chemical controls are becoming less effective due to the development of resistance in target pathogens, which pose significant environmental and health concerns.
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