JAK/STAT signaling in renal diseases. | LitMetric

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JAK/STAT signaling in renal diseases. | LitMetric

JAK/STAT signaling in renal diseases.

Peter Y Chuang John C He

Kidney Int

Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

Published: August 2010

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.

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http://dx.doi.org/10.1038/ki.2010.158	DOI Listing

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