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Identification of a novel heterozygous GPD1 missense variant in a Chinese adult patient with recurrent HTG-AP consuming a high-fat diet and heavy smoking.
BMC Med Genomics
January 2025
Department of Critical Care Medicine, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.
Background: Glycerol-3-phosphate dehydrogenase 1 (GPD1) gene defect can cause hypertriglyceridemia (HTG), which usually occurs in infants. The gene defect has rarely been reported in adult HTG patients. In the present study, we described the clinical and functional analyses of a novel GPD1 missense variant in a Chinese adult patient with recurrent hypertriglyceridemia‑related acute pancreatitis (HTG-AP), consuming a high-fat diet and smoking heavily.
View Article and Find Full Text PDFConstruction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma.
BMC Cancer
January 2025
Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, People's Republic of China.
Background: Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide. Various factors in the tumor environment (TME) can lead to the activation of endoplasmic reticulum stress (ERS), thereby affecting the occurrence and development of tumors. The objective of our study was to develop and validate a radiogenomic signature based on ERS to predict prognosis and systemic combination therapy response.
View Article and Find Full Text PDFNaturally occurring, rostrally conjoining chicken twins attempt to make a forebrain.
Dev Biol
January 2025
Institute of Life Sciences and Health (ILSH), School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. Electronic address:
Conjoined twinning is a special case of monozygotic, monoamniotic twinning. Human conjoined twinning, and vertebrate conjoined twinning in general, is a very rare phenomenon. It has been suggested that the risk of conjoined twinning increases with some medication and upon assisted reproduction.
View Article and Find Full Text PDFExploiting CotA laccase from Antarctic Bacillus sp. PAMC28748 for efficient mediator-assisted dye decolorization and ABTS regeneration.
Chemosphere
January 2025
Department of Life Science and Biochemical Engineering, Graduate School, SunMoon University, Asan, 31460, Republic of Korea; Genome-based Bio-IT Convergence Institute, Asan, 31460, Republic of Korea; Bio Big Data-based Chungnam Smart Clean Research Leader Training Program, SunMoon University, Asan, 31460, Republic of Korea; Department of Pharmaceutical Engineering and Biotechnology, SunMoon University, Asan, 31460, Republic of Korea. Electronic address:
Laccases are of particular interest in addressing environmental challenges, such as the degradation of triphenylmethane (TPM) dyes, including crystal violet (CV) and Coomassie Brilliant Blue (CBB), which are commonly used in SDS-PAGE for protein visualization. However, these dyes present significant environmental concerns due to their resistance to degradation, which makes their removal from industrial wastewater a major challenge. To address this, the current study investigates the potential of a novel CotA laccase derived from Bacillus sp.
View Article and Find Full Text PDFAssociations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study.
Ecotoxicol Environ Saf
January 2025
Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China. Electronic address:
Background: The influence of air pollution on osteoarthritis (OA) remains underexplored.
Methods: We conducted a prospective cohort study in the UK Biobank, estimating exposure levels of particulate matter (PM, PM, PM) nitrogen oxides (NO, NO), and air pollutants exposure score (APES). Cox models assessed associations between air pollution exposure and OA incidence, joint replacement, and survival.
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