The thermodynamic preference for the trans isomer of prolyl peptide bonds arises almost entirely from enthalpy in aqueous buffer and in toluene.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902179 | PMC |
http://dx.doi.org/10.1016/S0040-4039(00)93377-X | DOI Listing |
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