Many Polycomb group (PcG) proteins assemble into complexes containing histone-modifying enzymes that act in concert to control developmental regulators. In a recent study in Nature, Scheuermann et al. report the identification of a PcG complex with histone H2A-specific deubiquitinase activity that may be a key player in PcG-target gene regulation.
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| http://dx.doi.org/10.1016/j.devcel.2010.06.001 | DOI Listing |
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