AI Article Synopsis
- The study aimed to examine levels of serum homocysteine and asymmetric dimethylarginine (ADMA) in women with premature ovarian failure (POF) compared to healthy women.
- It involved 69 women - 32 with POF and 37 healthy controls, where fasting blood samples were analyzed using the ELISA method.
- Results showed no significant differences in homocysteine and ADMA levels between the two groups, indicating that estrogen deficiency in POF patients does not affect these biochemical markers.
Article Abstract
Objective: To investigate serum homocysteine and asymmetric dimethylarginine (ADMA) levels in patients with premature ovarian failure (POF).
Study Design: A total of 69 women, 32 with POF and 37 apparently healthy women were included in the study. Fasting blood samples were drawn to measure serum homocysteine and ADMA levels using ELISA method.
Results: The study and control group had a mean age of 37.3 + 2.6, 37.5 + 2.5 years; a mean homocysteine level of 13.54 + 5.19, 12.71 + 3.99 mmol/l and a mean ADMA level of 1.32 + 0.27, 1.26 + 0.36 mmol/l, respectively. There were no statistically significant differences between the two groups in terms of homocysteine and ADMA levels (with p values of 0.465 and 0.423, respectively). A negative significant correlation was found between estradiol and ADMA (p <0.05).
Conclusion: Homocysteine and ADMA levels did not change in comparison with the control group, which suggests that estrogen deficiency in patients with POF does not have any effect on homocysteine and asymmetric dimethylarginine levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/09513590.2010.502273 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!