AI Article Synopsis
- The study investigates how the expression of the Ki67 protein affects survival rates among pediatric patients with malignant gliomas, particularly anaplastic astrocytoma and glioblastoma multiforme.
- The research analyzed 21 patients, finding that 12 had elevated Ki67 levels; however, this overexpression did not significantly correlate with survival outcomes, although it did link to more aggressive tumor types.
- A critical finding is that being younger than 11 years old indicates a poorer prognosis for these patients, with an overall survival rate of 49% after 10 years.
Article Abstract
Background: Pediatric patients with malignant gliomas and same histological diagnosis respond distinctly to treatment. It is thus necessary to determine other factors that may influence the response to treatment and survival. Over expression of the Ki67 protein has been associated with poor treatment response. The aim of this study was to determine if the expression of this antigen influences survival of patients treated for malignant gliomas in the CMN SXXI Pediatrics Hospital.
Methods: We included patients with anaplasic astrocitoma or glioblastoma multiforme seen at our hospital between 1995 and 2005. We determined the expression of Ki67 by immunohistochemistry and correlated the findings with tumor histology and patient survival.
Results: Of the 21 patients studied, 12 overexpressed antigen Ki67. There was no significant association between over expression of Ki67 and survival, although we observed a clinical association. Over expression of Ki67 correlated with more aggressive histology. Being under the age of 11 was a poor prognostic factor. Overall survival was 49% at 120 months.
Conclusions: Being young (under 11 years) is a marker of poor prognosis among pediatric patients with anaplasic astrocytoma or glioblastoma multiforme. Overexpression expression of antigen Ki67 is associated with histology and may be associated with poor survival among patients treated in our hospital.
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