Cutaneous T cell-attracting chemokine (CTACK)/CCL27 and macrophage inflammatory protein (MIP)-3α/CCL20 are the major inflammatory chemokines involved in skin inflammation. The present study showed that roxithromycin (RXM) suppressed the TNFα-induced production of CCL27 and CCL20 in HaCaT keratinocytes and normal human keratinocytes (NHKs) in a dose-dependent manner. The production of CCL20 induced by TNFα was suppressed by the addition of inhibitors of nuclear factor kappa B (NFκB). RXM suppressed NFκB activity induced by TNFα. RXM, by regulating CCL27 and CCL20, may contribute to the modulation of inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00403-010-1068-x | DOI Listing |
Publication Analysis
Top Keywords
rxm suppressed
8
ccl27 ccl20
8
induced tnfα
8
roxithromycin downregulates
4
downregulates production
4
production ctack/ccl27
4
ctack/ccl27 mip-3α/ccl20
4
mip-3α/ccl20 epidermal
4
epidermal keratinocytes
4
keratinocytes cutaneous
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!