Metallo-ß-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ß-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ß-lactam, imipenem, in E. coli.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901175 | PMC |
| http://dx.doi.org/10.1021/ml900022q | DOI Listing |
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