A new intact glucosinolate Cinnamoyl derivative [6'-O-trans-(4″- hydroxy cinnamoyl)-4-(methylsulphinyl) butyl glucosinolate] (A) has been isolated from Broccoli (Brassica oleracea L. var. italica) florets. The compound was isolated and characterized by LC, MS-ESI, FTIR, (1)H and (13)C NMR as well as (1)H-(1)H COSY, DEPT 135° spectrometric experiments.
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http://dx.doi.org/10.1016/j.fitote.2010.06.030 | DOI Listing |
BMC Plant Biol
December 2024
Beichuan Shennong Agriculture Technology Development Co., Ltd, Mianyang, 621000, China.
Background: Magnolia officinalis (M. officinalis) thrives in temperate, elevated regions, and its desiccated bark comprises medicinal monolignol. Both abiotic and biotic factors can influence the pharmacodynamic compounds of M.
View Article and Find Full Text PDFEur J Med Chem
January 2025
Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.
J Ethnopharmacol
February 2025
Departament of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, campus Pampulha, Avenida Antônio Carlos 6627, 31.270-901, Belo Horizonte, MG, Brazil. Electronic address:
Ethnopharmacological Relevance: Echinodorus macrophyllus is a medicinal plant traditionally used in Brazil to treat rheumatic diseases. It is listed as a priority species for the development of herbal preparations for the Brazilian Unified Health System (SUS). Previous studies have demonstrated the anti-inflammatory and antiedematogenic properties of extracts and fractions from this species, but these preparations were neither standardized nor optimized for anti-arthritis effects.
View Article and Find Full Text PDFEur J Med Chem
October 2023
Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China. Electronic address:
In this work, we utilized the N-benzylaryl derivative 9 as a lead compound and employed the molecular hybridization strategy by introducing cinnamoyl fragments to successfully design and synthesize 33 novel N-benzylaryl cinnamide derivatives 15a∼15 ag. The in vitro antiproliferative activities were explored, and the preliminary analysis and summary of their structure-activity relationship were conducted. The majority of the compounds demonstrated significant inhibitory potency on MGC-803, HCT-116 and KYSE450 cells with IC values below 0.
View Article and Find Full Text PDFFree Radic Biol Med
November 2024
Department of Chemistry, King Saud University, 11451, Riyadh, Saudi Arabia; School of Medicine, Dentistry and Nursing, University of Glasgow, G12 8QQ, Glasgow, UK. Electronic address:
A mango pulp purée was ingested by ileostomists, whose colon had been removed surgically, and subjects with a full gastrointestinal (GI) tract, after which ileal fluid, urine and feces were collected over a 24 h period and analysed by UHPLC-HR-MS. The main (poly)phenols in the purée were gallotannins (356 μmol) and two hydroxy-methoxy-cinnamoyl glucose esters (43 μmol) together with the aromatic amino acids phenylalanine (22 μmol) and tyrosine (209 μmol). Analysis of ileal fluid revealed almost all the ingested gallotannins appeared to have broken down in the upper GI tract with the released benzoic acids being rapidly absorbed into the circulatory system prior to urinary excretion mainly as phase-2 metabolites.
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