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Halo Sign: Metastatic Cardiac Angiosarcoma Mimicking Fungal Infection.
Radiol Imaging Cancer
January 2025
From the Department of Radiology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH 44106.
Diagnostic Role of Endoscopic Ultrasound in Cardiac Angiosarcoma.
JACC Case Rep
January 2025
Cardiology Department, Schoen Hospital Neustadt, Holstein, Germany.
Primary cardiac tumors are a rare disease, with 20% of the cases being malignant. Among them, angiosarcoma is characterized by a short clinical course and poor prognosis, even after surgery, chemotherapy, and radiation therapy. We present a 67-year-old woman diagnosed with a primary malignant tumor (angiosarcoma) infiltrating the right atrial myocardium.
View Article and Find Full Text PDFUndifferentiated Pleomorphic Cardiac Sarcoma: A Rare and Often Fatal Diagnosis.
JACC Case Rep
December 2024
Wellington Hospital, Wellington, New Zealand.
Angiosarcomas are rare and often a fatal manifestation of cardiac tumors. This paper presents a case of a sarcoma with protrusion through the mitral valve. Angiographic findings demonstrated a tumor blush, supplied by the right coronary and left anterior descending arteries.
View Article and Find Full Text PDFSurgical Resected Cardiac Angiosarcoma in a 75-Year-Old Patient With a Mitral Valve Bioprosthesis.
JACC Case Rep
December 2024
Department of Nuclear Medicine, Hospital Clínico San Carlos, Madrid, Spain.
A 75-year-old patient with a history of mitral and aortic valve replacement surgery 7 years ago, presented with progressive dyspnea. Transesophageal echocardiogram showed a mass suggestive of bioprosthetic mitral valve thrombosis. We present the investigation process using imaging, surgical findings, nuclear medicine, and histopathology that result in the diagnosis of cardiac angiosarcoma.
View Article and Find Full Text PDFGenomic Profiling of Cardiac Angiosarcoma Reveals Novel Targetable KDR Variants, Recurrent MED12 Mutations and a High Burden of Germline POT1Alterations.
Clin Cancer Res
January 2025
Brigham and Women's Hospital, Boston, United States.
Purpose: Cardiac angiosarcoma (CAS) is a rare, aggressive malignancy with limited treatment options. Both sporadic and familial cases occur, with recent links to germline POT1 mutations. The genomic landscape of this disease is poorly understood.
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