AI Article Synopsis
- The study focused on the transformation of the bioactive compound (-)-mellein from a marine-derived fungus, Cladosporium sp.
- A culture with the bacterium Stappia sp. led to the creation of a new metabolite called (3R,4S)-4-hydroxymellein.
- The stereostructure of this new metabolite was determined through comprehensive analysis of physical and chemical data.
Article Abstract
The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marine-derived fungus Cladosporium sp., was studied. The preparative-scale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
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| http://dx.doi.org/10.4014/jmb.1002.02012 | DOI Listing |
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