Background: Collagen membranes have been developed to overcome the problem of limited availability of skin grafts. Vascularization and restricted functional epithelization limit the success of bioartificial constructs.
Objective: To compare the vascularization, epithelization, and integration of a porcine collagen I/III membrane with that of split-thickness skin grafts on skin wounds.
Materials And Methods: In 21 adult pigs, full-thickness skin defects on the rear side of the ear healed by split-thickness skin grafting, by covering with the membrane, or by free granulation. Skin samples on postoperative days 1, 3, 7, 14, 21, and 28 were evaluated histologically (hematoxylin-eosin, Sirius Red) and using immunohistochemistry (cytokeratin 5/6, transforming growth factor beta receptor (TGFbetaR-III) and immunoblot (TGFbeta(1,3), Smad2/3). Epithelial thickness and TGFbetaR-III-positive capillary area were quantitatively assessed.
Results: Epithelization and vascularization in the membrane group were not significantly different from in the group treated with a split-thickness skin graft. Free granulation showed significantly slower epithelization and vascularization (p<.05). TGFbeta(1) and Smad2/3 complex expression were high during free granulation. Matrix was distinguishable until day 7.
Conclusions: This membrane serves as a suitable full-thickness dermal substitute, because the membrane is vascularized faster than free granulation tissue and enables early epithelization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1524-4725.2010.01569.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background And Aims: This systematic review and meta-analysis evaluate the efficacy of moist versus non-moist dressings for split-thickness skin graft (STSG) donor sites, focusing on time to healing, pain management, and adverse events to guide clinical practice.
Methods: A comprehensive literature search was conducted across databases including Ovid/MEDLINE, Embase, Cochrane CENTRAL, Cochrane Database of Systematic Reviews, and Scopus up to November 28, 2023. The study adhered to PRISMA guidelines.
Recalcitrant Bilateral Volar Hand Burn Contracture in a Toddler Treated With Integra and Staged Full-thickness Skin Graft: A Literature Review.
Plast Reconstr Surg Glob Open
January 2025
Division of Academic Affairs, University of Arkansas for Medical Sciences Library, Little Rock, AR.
Background: Recurrent burn contractures on the volar aspect of the hand present a formidable challenge, especially in the pediatric patient. We used Integra followed by staged full-thickness skin grafting for recurrent bilateral volar hand burn contracture in a toddler. We reviewed the literature to appraise the utility of full-thickness skin graft (FTSG) combined with Integra used for volar hand contractures.
View Article and Find Full Text PDFStreptococcus pyogenes M1UK Variant-Associated Sartorius Muscle Necrotizing Soft Tissue Infection: A Case Report and Literature Review.
Cureus
December 2024
Laboratory of Infectious Diseases, Graduate School of Infection Control Sciences & Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, JPN.
Necrotizing soft tissue infections (NTSIs) represent a concept of necrotizing infections involving the skin, subcutaneous tissue, fascia, and muscle, and it is a potentially fatal disease. Early exploratory incision is strongly recommended for both the diagnosis and treatment of necrotizing soft tissue infections. Treatment of necrotizing soft tissue infections requires the administration of appropriate antimicrobial agents and adequate surgical debridement.
View Article and Find Full Text PDFA Case of Fournier's Gangrene Secondary to Varicella Zoster Virus in a 7-Year-Old Boy.
Case Rep Surg
January 2025
Department of Plastic and Reconstructive Surgery, Cork University Hospital, Cork, County Cork, Ireland.
A rare case of Fournier's gangrene (FG) secondary to varicella-zoster virus (VZV) affecting the penis and scrotum of a 7-year-old boy is presented. To the authors' knowledge, there are four cases of FG in children as a result of VZV reported to date. Our patient underwent a total of four surgical debridements and was reconstructed using a split-thickness skin graft (SSG).
View Article and Find Full Text PDFTreatment of exposed tibial bone by old school burr holes - a case report.
Acta Chir Plast
January 2025
Background: We report a successful wound treatment of a chronic ulcer with bone exposure using a somehow forgotten technique of creating burr holes into the bone. Most clinics would promote flap surgery to cover wounds with bone exposure, however, in some cases invasive surgery is not mandatory. We bring up an alternative treatment for such cases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!