We introduce the general pinhole camera (GPC), defined by a center of projection (i.e., the pinhole), an image plane, and a set of sampling locations in the image plane. We demonstrate the advantages of the GPC in the contexts of remote visualization, focus-plus-context visualization, and extreme antialiasing, which benefit from the GPC sampling flexibility. For remote visualization, we describe a GPC that allows zooming-in at the client without the need for transferring additional data from the server. For focus-plus-context visualization, we describe a GPC with multiple regions of interest with sampling rate continuity to the surrounding areas. For extreme antialiasing, we describe a GPC variant that allows supersampling locally with a very high number of color samples per output pixel (e.g., 1,024{\times}), supersampling levels that are out of reach for conventional approaches that supersample the entire image. The GPC supports many types of data, including surface geometry, volumetric, and image data, as well as many rendering modes, including highly view-dependent effects such as volume rendering. Finally, GPC visualization is efficient-GPC images are rendered and resampled with the help of graphics hardware at interactive rates.
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http://dx.doi.org/10.1109/TVCG.2010.22 | DOI Listing |
Methods Mol Biol
December 2024
Viral Special Pathogens Branch, Division of High-Consequence Pathogens & Pathology, Centers for Disease Control & Prevention, Atlanta, GA, USA.
Reverse genetic systems are powerful tools in molecular virology that allow the generation of infectious recombinant virus and the manipulation of viral genomes. Reverse genetic systems enable the incorporation of reporter genes, facilitating many virological assays, including high-throughput screening. Additionally, reverse genetic systems can be used to introduce targeted mutations into the viral genome, allowing investigations of viral genetic elements and protein functions in virus pathogenesis and biology.
View Article and Find Full Text PDFInt J Clin Exp Pathol
November 2024
Instituto de Salud Pública, Universidad Veracruzana Xalapa, Veracruz, México.
The hepatocarcinoma (HCC) is the most important liver tumor. It represents 90% of liver cancer cases. One of the main problems is the limited prompt cancer diagnosis and the advanced stages where the chances of treatment are limited.
View Article and Find Full Text PDFmedRxiv
October 2024
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, USA.
Chem Sci
September 2024
Department of Chemistry, Molecular Engineering & Science Institute, University of Washington 36 Bagley Hall Seattle WA 98195 USA
Bottlebrush polymers represent an important class of macromolecular architectures, with applications ranging from drug delivery to organic electronics. While there is an abundance of literature describing the synthesis, structure, and applications of linear bottlebrush polymers using ring-opening metathesis polymerization (ROMP), there are comparatively less reports on their cyclic counterparts. This lack of research is primarily due to the difficulty in synthesizing cyclic bottlebrush polymers, as extensions of typical routes towards linear bottlebrush polymers (, "grafting-through" polymerizations of macromonomers with ROMP) produce only ultrahigh molar mass cyclic bottlebrush polymers with poor molar mass control.
View Article and Find Full Text PDFJ Virol
October 2024
California NanoSystems Institute, University of California, Los Angeles, California, USA.
Unlabelled: Arenaviruses exist globally and can cause hemorrhagic fever and neurological diseases, exemplified by the zoonotic pathogen lymphocytic choriomeningitis virus (LCMV). The structures of individual LCMV proteins or their fragments have been reported, but the architectural organization and the nucleocapsid assembly mechanism remain elusive. Importantly, the structure of the arenavirus fusion protein complex (glycoprotein complex, GPC) as present on the virion prior to fusion, particularly with its integral stable signal peptide (SSP), has not been shown, hindering efforts such as structure-based vaccine design.
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