Indirect blood pressure measurements using high definition oscillometric (HDO) and Doppler devices were compared in 50 anaesthetised client-owned cats presented for various surgical procedures. Sites of cuff placement for Doppler were identified as forelimb and hindlimb and for HDO as forelimb and tail. Oscillometric and Doppler readings were obtained in 90.05% and 100% of attempts, respectively. Both devices enabled precise measurement of systolic arterial pressure (SAP), although the Doppler device gave higher precision. In the low pressure group (SAP<100 mmHg; n=30), 66.7% biases were within 10 mmHg of discrepancy, but in groups of normal (100 mmHg ≤ SAP ≤ 150 mmHg; n=120) and high measurements (SAP>150 mmHg; n=62), 86.7% and 75.0% of discrepancy, respectively, were lower than 10 mmHg. Frequency of discrepancy at the range of 15 mmHg showed similar differences between pressure groups. There were significantly higher discrepancies when the cuff was positioned on the tail rather than on the leg. The SAP value obtained by HDO can be calculated from the Doppler measurement from SAP (HDO)=0.8515 × SAP (Doppler)+19.221 mmHg. Compared to Doppler, HDO overestimated low pressure and underestimated high pressure values.
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http://dx.doi.org/10.1016/j.jfms.2010.04.007 | DOI Listing |
Tumour 'bulk' has historically been considered an important prognostic marker and clinical tool to guide treatment in patients with lymphoma. However, its use and definitions in trial designs varies significantly and it is unclear how this has influenced the relevance of bulk in contemporary practice. This comprehensive literature review evaluated the definitions, applications and prognostic impact of bulk in phase 3 randomised trials in four major lymphoma subtypes.
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