AI Article Synopsis
- Two new antioxidants, obtusilactone A and (-)-sesamin, were discovered in the plant Cinnamomum kotoense.
- Both antioxidants demonstrated strong DPPH radical scavenging ability, outperforming vitamin C, and showed better reducing power compared to BHA.
- The findings suggest that these compounds could serve as natural antioxidants with potential benefits in cancer prevention.
Article Abstract
Two novel antioxidants, obtusilactone A (1) and (-)-sesamin (2) have been identified in Cinnamomum kotoense Kanehira. Both showed effective 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with vitamin C, and reducing power compared with BHA. These results suggest that these constituents of C. kotoense act as natural antioxidants and play a potential role in cancer prevention.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The complete chloroplast genome sequence of .
Mitochondrial DNA B Resour
December 2019
Laboratory of Forest Plant Cultivation and Utilization, Yunnan Academy of Forestry, Kunming, People's Republic of China.
The first complete chloroplast genome (cpDNA) sequence of was determined from Illumina HiSeq pair-end sequencing data in this study. The cpDNA is 154,010 bp in length, contains a large single copy region (LSC) of 93,676 bp and a small single copy region (SSC) of 18,830 bp, which were separated by a pair of inverted repeats (IR) regions of 20,752 bp. The genome contains 127 genes, including 82 protein-coding genes, 8 ribosomal RNA genes, and 36 transfer RNA genes.
View Article and Find Full Text PDFIsokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and Apoptosis and .
Oxid Med Cell Longev
May 2021
College of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Melanoma is an aggressive cancer with high lethality. In order to find new anticancer agents, isokotomolide A (Iso A) and secokotomolide A (Sec A) isolated from were identified to be potential bioactive agents against human melanoma but without strong antioxidative properties. Cell proliferation assay displayed Iso A and Sec A treated in the normal human skin cells showed high viabilities.
View Article and Find Full Text PDFEnhancement of Bone Marrow-Derived Mesenchymal Stem Cell Osteogenesis and New Bone Formation in Rats by Obtusilactone A.
Int J Mol Sci
November 2017
Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
The natural pure compound obtusilactone A (OA) was identified in Kanehira & Sasaki, and shows effective anti-cancer activity. We studied the effect of OA on osteogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). OA possesses biocompatibility, stimulates Alkaline Phosphatase (ALP) activity and facilitates mineralization of BMSCs.
View Article and Find Full Text PDFIsoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5.
J Agric Food Chem
April 2012
Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung, Taiwan, Republic of China.
Hepatoma cells are relatively resistant to TRAIL. We have previously shown that isoobtusilactone A (IOA), a potent anticancer agent isolated from Cinnamomum kotoense, induced mitochondria-mediated apoptosis in hepatoma cells. Here, we report that IOA could potentiate TRAIL-induced apoptosis in Hep G2 cells.
View Article and Find Full Text PDFObtusilactone A and (-)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints.
Cancer Sci
December 2010
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Several compounds from Cinnamomum kotoense show anticancer activities. However, the detailed mechanisms of most compounds from C. kotoense remain unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!