AI Article Synopsis
- This study is the largest investigation of human exposure to the radionuclide 210Po, focusing on 4402 white male workers at the Mound Facility from 1944 to 1972.
- No excess mortality was found among these workers, although those hired during World War II showed elevated deaths from various cancers, particularly lung and rectal cancers, which do not seem linked to 210Po exposure.
- Among workers monitored for 210Po, overall mortality was lower than expected, but there were more lung cancer cases than anticipated, with no clear dose-response trends found for any cancer types.
Article Abstract
This study represents the largest epidemiologic investigation of humans exposed to the radionuclide 210Po. In a cohort of 4402 white males employed by the Mound Facility, during the period when Po operations were conducted (1944-1972), no excess mortality was observed. Among workers initially hired during World War II, mortality was elevated, especially for deaths from all cancers, cancers of the lung, and cancers of the rectum. These adverse health events do not appear related to exposure to 210Po. Among workers monitored for 210Po, mortality was significantly less than expected, although more lung cancers were observed than expected. No significant dose-response trends were identified for all causes combined, all cancers combined, or for cause-specific cancers among the Po-monitored subcohort. Continued follow-up of this cohort is planned.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00004032-199107000-00007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A qualitative exploration of the enablers of and barriers to conformance with antibiotic withdrawal periods on smallholding, peri-urban pig farms in Kiambu County, Kenya.
PLoS One
January 2025
Animal and Human Health Department, International Livestock Research Institute, Nairobi, Kenya.
Non-conformance with antibiotic withdrawal period guidelines represents a food safety concern, with potential for antibiotic toxicities and allergic reactions as well as selecting for antibiotic resistance. In the Kenyan domestic pig market, conformance with antibiotic withdrawal periods is not a requirement of government legislation and evidence suggests that antibiotic residues may frequently be above recommended limits. In this study, we sought to explore enablers of and barriers to conformance with antibiotic withdrawal periods for pig farms supplying a local independent abattoir in peri-urban Nairobi.
View Article and Find Full Text PDFEcofriendly and biocompatible biochars derived from waste-branches for direct and efficient solid-phase extraction of benzodiazepines in crude urine sample prior to LC-MS/MS.
Mikrochim Acta
January 2025
School of Public Health, Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, North China University of Science and Technology, No. 21 Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China.
Biochars (BCs) derived from waste-branches of apple tree, grape tree, and oak were developed for direct solid-phase extraction (SPE) of five benzodiazepines (BZDs) in crude urine samples prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) determination. Scanning electron microscopy, elemental analyzer, X-ray diffractometry, N adsorption/desorption experiments, and Fourier transform infrared spectrometry characterizations revealed the existence of their mesoporous structure and numerous oxygen-containing functional groups. The obtained BCs not only possessed high affinity towards BZDs via π-π and hydrogen bond interactions, but also afforded the great biocompatibility of excluding interfering components from undiluted urine samples when using SPE adsorbents.
View Article and Find Full Text PDFSupplemental Operational Guidance for Minimizing Potential Inhalation Doses to Workers and Volunteers at Community Reception Centers and Public Shelters.
Health Phys
January 2025
Radiation Studies Section, Division of Environmental Health Science and Practice, Centers for Disease Control and Prevention, Atlanta, GA.
In the event of a nuclear explosion in an urban environment, contaminated persons may be directed to Community Reception Centers (CRC) and/or public shelters. This paper is a companion document to a previous paper that addresses the inhalation hazard to workers at a CRC from resuspension of fallout from the evacuees. To limit the inhalation hazard evacuees must be screened to prevent severely contaminated persons from entering a CRC.
View Article and Find Full Text PDFPerceptions of healthcare workers on implementing the 2022 WHO verbal autopsy instrument in rural India through the existing public health system.
J Family Med Prim Care
December 2024
Indian Council of Medical Research, Ansari Nagar, New Delhi, India.
Background: Cause-of-death (CoD) information is crucial for health policy formulation, planning, and program implementation. Verbal Autopsy (VA) is an approach employed for the collection and analysis of CoD estimates at the population level where medical certification of cause of death is low and, secondly, for integrating it with the existing public health system by utilizing the grassroots level workforce.
Objective: The study aims to understand the field perspectives on implementing the 2022 WHO VA instrument in rural India through the existing public health system.
The role of hospital pharmacists in supporting the appropriate and safe use of CGT/ATMPs: a scoping review of current insights.
BMC Health Serv Res
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.
Background: The role of hospital pharmacists in managing cell and gene therapy (CGT) and advanced therapy medicinal products (ATMPs) is gradually being recognized but the evidence about impact of their role has not been systematically reported.
Objective: This study was aimed to summarize the professional services provided by hospital pharmacists on managing CGT/ATMPs and the evidence about the effects on patient care, as well as to identify the perceptions about pharmacists assuming a role that supports the appropriate and safe use of CGT/ATMPs.
Methods: Literature from 4 electronic databases (PubMed, ScienceDirect, Web of Science, Scopus) were searched following PRISMA checklist to yield publications on the interventions provided by hospital pharmacists in the management of CGT/ATMPs dated since 1 January 2013 till 30 April 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!