Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107033 | PMC |
| http://dx.doi.org/10.1039/c0cc01419b | DOI Listing |
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