AI Article Synopsis
- The study examined the mutagenic and genotoxic effects of metolcarb using two main methods: bacterial reverse mutation assays with Salmonella strains and the Allium cepa root growth test.
- It was found that metolcarb could cause mutations in S. typhimurium TA98 at certain doses, and in onion root tests, it inhibited growth with an EC50 value of 200 ppm.
- Various cell abnormalities were observed, such as disturbed anaphase-telophase and polyploidy, indicating that metolcarb has significant effects on cell division and genetic integrity.
Article Abstract
Mutagenic and genotoxic effects of metolcarb were investigated by both bacterial reverse mutation assay in Salmonella typhimurium TA97, TA98, TA100 and TA102 strains with or without metabolic activation system (S9) and Allium cepa root meristematic cells, respectively. Metolcarb was dissolved in DMSO in Ames/Salmonella test system. 0.1, 1 and 10 microg/plate doses of metolcarb were found to be mutagenic S. typhimurium TA98 without S9. In Allium root growth inhibition test, EC50 value was determined 200 ppm and 0.5xEC50, EC50 and 2xEC50 concentrations of metolcarb were introduced to onion tuber roots and distilled water used as a negative control. Mitotic index (MI), increased in all concentrations compared to control at each exposure time. While disturbed anaphase-telophase, chromosome laggards, stickiness and bridges were observed in anaphase-telophase cells, pro-metaphase, C-mitosis, polyploidy, binuclear cells and disturbed nucleus were observed in other cells. The results were also analyzed statistically by using SPSS for Windows, Mann-Whitney test and Duncan's multiple range tests were performed respectively.
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| http://dx.doi.org/10.1016/j.chemosphere.2010.05.011 | DOI Listing |
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