AI Article Synopsis
- * Each sensory neuron soma is surrounded by satellite glial cells (SGCs), which interact with the neurons without forming direct synapses, making their influence on neuronal activity indirect.
- * Recent research highlights how ATP released from neuron somas activates SGCs, leading to complex modulatory effects on neuronal activity, indicating that SGCs play a significant role in processing sensory information.
Article Abstract
It has been known for some time that the somata of neurons in sensory ganglia respond to electrical or chemical stimulation and release transmitters in a Ca2+-dependent manner. The function of the somatic release has not been well delineated. A unique characteristic of the ganglia is that each neuronal soma is tightly enwrapped by satellite glial cells (SGCs). The somatic membrane of a sensory neuron rarely makes synaptic contact with another neuron. As a result, the influence of somatic release on the activity of adjacent neurons is likely to be indirect and/or slow. Recent studies of neuron-SGC interactions have demonstrated that ATP released from the somata of dorsal root ganglion neurons activates SGCs. They in turn exert complex excitatory and inhibitory modulation of neuronal activity. Thus, SGCs are actively involved in the processing of afferent information. In this review, we summarize our understanding of bidirectional communication between neuronal somata and SGCs in sensory ganglia and its possible role in afferent signaling under normal and injurious conditions. The participation of purinergic receptors is emphasized because of their dominant roles in the communication.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120217 | PMC |
| http://dx.doi.org/10.1017/S1740925X10000116 | DOI Listing |
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