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Push toward pre-emptive kidney transplantation - for sure?
Clin Kidney J
December 2024
INSERM Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University, Villejuif, France.
Pre-emptive kidney transplantation (PKT) has long been considered the optimal treatment for patients with end-stage chronic kidney disease (CKD) seeking the most favourable long-term outcomes. However, the significant growth in transplant procedures over recent decades has led to a notable increase in wait-listed patients and a disproportionate demand for donor organs. This situation necessitates a re-evaluation of transplantation timing and the establishment of rational indications from both societal and clinical perspectives.
View Article and Find Full Text PDFFirst ABO-Incompatible Pediatric Kidney Transplant in South Africa-A Case Report.
Pediatr Transplant
February 2025
University of Cape Town, Cape Town, South Africa.
Background: Blood group incompatibility previously represented an obstacle to living related donor (LRD) options; desensitization modalities have expanded LRD options. ABO-incompatible kidney transplants have been successful in adults and pediatric liver transplants, but to date not yet in pediatric kidney transplants in South Africa.
Case Report: Patient X is a 5 year old male with end-stage kidney failure due to Posterior Urethral Valves, requiring peritoneal dialysis pre-transplant.
Underappreciated Effects of Delayed Graft Function in Pediatric Kidney Transplantation.
Pediatr Transplant
February 2025
Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Purpose: In kidney transplantation (KT), delayed graft function (DGF) is associated with worse outcomes. However, it is unclear what effect DGF plays in long-term survival compared to the impact of the various transplant, donor, and recipient risk factors associated with DGF. This study aims to determine the effect of DGF alone on long-term survival in pediatric deceased donor kidney transplant recipients (DDKTRs).
View Article and Find Full Text PDFLong-term outcomes of kidney replacement therapy in Australians with prune belly syndrome.
J Paediatr Child Health
December 2024
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Article Synopsis
- * A total of 37 males with PBS were analyzed, with most starting KRT in their teens; half underwent kidney transplants, showing good graft survival rates at 1, 5, and 10 years.
- * The findings indicated that while there was variation in individual outcomes for PBS patients, their overall transplant and dialysis survival rates were similar or better than those of the control group.
Pre-emptive use of glucose 5% as the standard drug solvent reduces hypernatremia in critically ill patients.
Clin Kidney J
November 2024
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Nephrology and Medical Intensive Care, Augustenburger Platz 1, Berlin, Germany.
Article Synopsis
- Hypernatremia is a common and serious condition in ICU patients, linked to higher mortality and longer stays, prompting this study to compare sodium chloride 0.9% and glucose 5% solutions as intravenous drug diluents.
- The study analyzed 265 adult COVID-19 patients, observing sodium levels and severe hypernatremia over the first 8 days after ICU admission, finding that glucose 5% led to lower sodium levels and reduced occurrences of severe hypernatremia.
- The results suggest that switching to glucose 5% as the standard diluent can help prevent hypernatremia in ICU patients, indicating a potentially simple change in treatment protocols.
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