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Modeling Liver Fibrosis Progression in Patients With Viral Hepatitis Using the Machine Learning Tool Subtype and Stage Inference (SuStaIn).
Cureus
February 2025
Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, JPN.
Background and aim The natural progression of liver fibrosis and its association with biomarker changes have not been fully established in the literature. This study aimed to investigate liver fibrosis progression in patients with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection using a novel machine learning tool called 'Subtype and Stage Inference (SuStaIn).' SuStaIn can identify disease progression patterns and subgroups from cross-sectional biomarker data.
View Article and Find Full Text PDFSCGB1A1 as a Key Regulator of Splenic Immune Dysfunction in COPD: Insights From a Murine Model.
Int J Chron Obstruct Pulmon Dis
March 2025
Department of Respiratory and Critical Care Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disorder characterized by irreversible airflow limitation and systemic immune impacts. COPD patients demonstrate an increased susceptibility to sepsis and septic shock, underscoring the importance of understanding its effects on splenic function.
Methods: A rat COPD model was established using lipopolysaccharide (LPS) and cigarette smoke exposure.
Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice.
Emerg Microbes Infect
March 2025
State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
The newly emerged avian influenza A H5N1 Clade 2.3.4.
View Article and Find Full Text PDFReal-world pharmacovigilance investigation of imipenem/cilastatin: signal detection using the FDA Adverse Event Reporting System (FAERS) database.
Front Pharmacol
February 2025
Department of Hepato-Biliary and Pancreato-Splenic Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.
Background: Although imipenem/cilastatin (IMI/CIL) has demonstrated favorable therapeutic efficacy against various infections, the incidence of potential adverse events (AEs) has escalated in parallel with its increased utilization and has been documented in clinical trials. However, a comprehensive understanding of real-world implications remains lacking.
Methods: By conducting a comprehensive search in the FDA Adverse Event Reporting System (FAERS) database, AE reports associated with IMI/CIL as the primary suspect (PS) were selected for analysis, spanning from the first quarter of 2004 to the fourth quarter of 2023.
Dialdehyde starch-epicatechin gallate conjugate alleviates inflammation in lipopolysaccharide-stimulated RAW264.7 cells and dextran sulfate sodium-induced colitis mice.
Int J Biol Macromol
February 2025
College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China. Electronic address:
In this study, epicatechin gallate (ECG), a natural anti-inflammatory agent, was conjugated onto dialdehyde starch (DAS) to achieve high physiological stability. The anti-inflammatory effect of DAS-ECG conjugate was evaluated by lipopolysaccharide (LPS)-stimulated RAW264.7 cells and dextran sulfate sodium (DSS)-induced colitis mice models.
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