AI Article Synopsis
- The study aimed to assess the expectorant and antitussive (cough-suppressing) effects of a traditional Chinese medicine, specifically testing Reineckia carnea.
- The research involved administering different fractions of the plant extract to mice with induced coughs and measuring their coughing behavior and mucus production.
- Results showed that the 90% ethanol fraction increased the time before coughing started, while the 60% ethanol fraction effectively reduced both cough frequency and mucus secretion, indicating potential therapeutic benefits of these extracts for respiratory issues.
Article Abstract
Aim Of Study: To evaluate the potential expectorant and antitussive activity of a traditional Chinese medicine.
Materials And Methods: The water extract and four fractions of the aerial part of Reineckia carnea were orally administrated to coughing mice induced by ammonium hydroxide and mice injected with phenol red, respectively, to investigate their medification effect on coughing and mucus secretion.
Results And Discussion: 90% Ethanol fraction significantly lengthened the latent period of cough and decreased cough frequency caused by ammonium hydroxide at the dose of 0.372 g/kg (p<0.05). Sixty percent ethanol fraction reduced the cough frequency as well as the mucus secretion from mouse tracheas obviously at the dose of 0.570 g/kg (p<0.05) by measuring the tracheal output of phenol red in mice. The medication effects in multiple doses of the active fractions were then performed and it has been proved that the 60% ethanol and 90% ethanol fraction were curatively effective on expectoration and coughing, respectively both at the high and middle dose, which supplied proofs for the further research on chemical constituents in both of two effective fractions.
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| http://dx.doi.org/10.1016/j.jep.2010.06.024 | DOI Listing |
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