AI Article Synopsis
- Chimeric Virus-Like Particles (VLPs) from papaya mosaic virus (PapMV) and malva mosaic virus (MaMV) can provoke a cytotoxic T lymphocyte (CTL) response by presenting epitopes on MHC class I molecules.* -
- Both types of VLPs were able to enter human antigen-presenting cells (APCs), leading to the cross-presentation of antigens in activated B lymphocytes and promoting the growth of specific T lymphocytes in vitro.* -
- High levels of chimeric MaMV were found to cause cell death in cultured cells, indicating that modifications to the VLPs could have unintended effects, but overall, potexvirus VLPs
Article Abstract
Chimeric VLPs made of papaya mosaic virus (PapMV) trigger a CTL response through antigenic presentation of epitopes on MHC class I. Here, a chimeric VLP composed of malva mosaic virus (MaMV) was shown to share similar properties. We demonstrated the capacity of both VLPs to enter human APCs. The chimeric constructions were cross-presented in CD40-activated B lymphocytes leading to in vitro expansion of antigen-specific T lymphocytes. We showed that high concentrations of chimeric MaMV induced cell death, suggesting that some modifications can trigger collateral effects in vitro. Results suggest that potexvirus VLPs are an attractive vaccine platform for inducing a CTL response.
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| http://dx.doi.org/10.1016/j.vaccine.2010.06.024 | DOI Listing |
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