We report an original method for implanting bone marrow stem cells within the spinal cord parenchyma. This method was used for the experimental treatment of patients diagnosed with amyotrophic lateral sclerosis. The methodology is reproducible and devoid of major complications even in patients showing significant spinal atrophy. Therefore, this report describes a surgical procedure that could be used in other experimental treatments involving the intraspinal delivery of stem cells.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2010.06.014DOI Listing

Publication Analysis

Top Keywords

spinal cord
8
amyotrophic lateral
8
lateral sclerosis
8
stem cells
8
surgical technique
4
technique spinal
4
cord cell
4
cell transplantation
4
transplantation amyotrophic
4
sclerosis report
4

Similar Publications

Article Synopsis
  • Acute transverse myelitis (ATM) is a serious neurological disorder involving spinal cord inflammation, leading to sensory, motor, and autonomic issues.
  • A 29-year-old woman experienced severe lower limb weakness, urinary issues, and sensory loss, with MRI confirming ATM and HCV infection present in her blood.
  • The case underscores the need for awareness of ATM as a possible complication of hepatitis C, especially when there is infective endocarditis (IE) involved, as confirmed by blood cultures showing bacteria linked to IE.
View Article and Find Full Text PDF

Background: To investigate the incidence, demographic characteristics, etiologies, surgical interventions, hospital stays, and neurologic outcomes associated with watersport-related traumatic spinal cord injuries (TSCI) in New Zealand.

Methods: Retrospective study collected data from New Zealand's two spinal rehabilitation units, the Auckland Spinal Rehabilitation Unit (ASRU) and the Burwood Spinal Unit (BSU). It included adults aged over 16 years, between January 2007 and December 2021 with new TSCI secondary to traumatic watersport activities.

View Article and Find Full Text PDF

Protective Effects of Heat-Killed Lactobacilli against Plasma-Induced Neurotoxicity in Multiple Sclerosis.

Probiotics Antimicrob Proteins

January 2025

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Heat-killed lactobacilli seem to have protective effects against oxidative stress and neurotoxicity. This study aimed to evaluate the antioxidant properties of specific heat-killed lactobacilli extracts and determine their neuroprotective effects against the neurotoxicity induced by blood plasma from people with multiple sclerosis (MS). The antioxidant activity of the three heat-killed lactobacilli was measured using the DPPH assay.

View Article and Find Full Text PDF

Background: With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need for biomarkers for disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation and quantification in vivo. This study aims to assess SC GM atrophy in patients with 5q-SMA and its associations with clinical disability.

View Article and Find Full Text PDF

Acute hypoalgesic and neurophysiological responses to lower-limb ischaemic preconditioning.

Exp Brain Res

January 2025

Faculty of Sport, Technology and Health Sciences, St. Mary's University, Twickenham, Middlesex, UK.

The aim of this study was to assess if ischaemic preconditioning (IPC) can reduce pain perception and enhance corticospinal excitability during voluntary contractions. In a randomised, within-subject design, healthy participants took part in three experimental visits after a familiarisation session. Measures of pressure pain threshold (PPT), maximum voluntary isometric force, voluntary activation, resting twitch force, corticospinal excitability and corticospinal inhibition were performed before and ≥10 min after either, unilateral IPC on the right leg (3 × 5 min); a sham protocol (3 × 1 min); or a control (no occlusion).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!