AI Article Synopsis
- The study aimed to explore brain structure differences in newly diagnosed, drug-free patients with major depressive disorder and panic disorder compared to healthy individuals.
- Utilizing high-resolution magnetic resonance imaging and voxel-based morphometry, researchers found significant reductions in gray matter volumes in multiple brain regions, including the anterior cingulate cortex and limbic areas among patients.
- The results indicate that these gray matter volume deficits may be linked to the default-mode network and could have begun at the onset of the disorders.
Article Abstract
This study was designed to investigate the structural differences in the brains of first episode, drug-naïve patients with major depressive disorder and panic disorder versus healthy control subjects. High-resolution brain magnetic resonance images were performed on patients and health control subjects (age, sex and handedness matched). Structural magnetic resonance images of brain were estimated by optimized voxel-based morphometry of FSL (FMRIB Software Library). Patients had deficits of gray matter volumes over right anterior cingulate cortex, right medial frontal gyrus, left posterior cingulate cortex, right parahippocampal gyrus, limbic areas, occipital lingual gyrus and bilateral cerebellums when compared to controls. These results suggested that this group of patients has possible deficits of gray matter volumes over the default-mode network, fronto-cingulate and limbic structures. The decline of gray matter volumes might have started since the first episode.
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| http://dx.doi.org/10.1016/j.euroneuro.2010.06.002 | DOI Listing |
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