Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
Published: August 2010
AI Article Synopsis
Article Abstract
Design, syntheses and structure-activity relationships of N-acetylated piperazine privileged structures containing MC4R agonist compounds were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties.
Background Of Study: Old age is a privilege for a second childhood and a new stage of opportunity and strength. Older adults are the most rapidly growing segment of the population. By 2050, 80% of all older people will live in low- and middle-income countries.
S.C. Patologie Diabetiche, Dipartimento Specialistico Territoriale, Azienda Sanitaria Giuliano Isontina - Dipartimento Universitario Clinico di Scienze Mediche, Chirurgiche e della Salute, Università degli Studi, Trieste.
The world of chronic non-communicable diseases is progressively growing epidemiologically, requiring a significant commitment of resources, continuity of care, and strong integration between healthcare professionals and care settings. The National Recovery and Resilience Plan, in the Ministerial Decree 77 of 23/5/2022, identifies Community Homes as the privileged location for providing integrated, multidisciplinary and multiprofessional interventions, involving specialists and nursing clinics, general practitioners and district structures, utilizing all the necessary technological equipment, including digital platforms for telemedicine. In this context, cardiology is facing a complicated challenge: cardiologists must take care of patients with cardiovascular diseases who have also complex comorbidities and are required to extend their knowledge beyond the specific, sometimes super-specialistic, cardiovascular field, to avoid fragmentation, redundancy, and potential conflicts in the diagnostic-therapeutic care pathways.
The privileged fused-ring system comprising the bicyclo[2.2.2]diazaoctane (BDO) core is prevalent in diketopiperazine (DKP) natural products with potent and diverse biological activities, with some being explored as drug candidates.
Addressing health inequities in health professions education is essential for preparing healthcare workers to meet the demands of diverse communities. While simulation has become a widely recognized and effective method for providing safe and authentic clinical learning experiences, there has been limited attention towards the power of simulation in preparing health practitioners to work with groups who experience health disparities due to systems of inequality. Balancing technical proficiency with educational approaches that foster critical reflection and inform action oriented towards social accountability is essential.
The quality of life of queer individuals in India is a result of a complex sociopolitical climate which is what this study aims to explore through qualitative methodology. Previous research has explored the social factors that impact the wellbeing of LGBT individuals in western countries, while the impact of politics on the wellbeing of marginalized groups is still largely unexplored. Through thematic analysis, this study found that family support and peer networks are the two most important social structures that determine the quality of life of LGBT emerging adults in India, whereas the impact of politics on wellbeing depends on the level of political awareness of the participants and their socio-political privilege in terms of caste, class and gender.
