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Template-assembly activation of primer exchange reaction for on-site and sensitive detection of copper ions in blood.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China; Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, PR China. Electronic address:
The sensitive and accurate detection of copper ions is crucial for public health, medical research, and environmental monitoring. In this study, we developed a sensor based on template-assembly activation of the primer exchange reaction (PER) for the on-site detection of copper ions in blood. Copper ions triggered the assembly of two template fragments into a hairpin structure via a click-chemistry reaction, activating the PER.
View Article and Find Full Text PDFMultifolding Vertical-Flow Electrochemical Paper-Based Devices with Tunable Dual Preconcentration for Enhanced Multiplexed Assays of Heavy Metals.
Anal Chem
January 2025
Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens 157 71, Greece.
This work describes fully integrated multifolding electrochemical paper-based devices (ePADs) for enhanced multiplexed voltammetric determination of heavy metals (Zn(II), Cd(II), and Pb(II)) using tunable passive preconcentration. The paper devices integrate five circular sample preconcentration layers and a 3-electrode electrochemical cell. The hydrophobic barriers of the devices are drawn by pen-plotting with hydrophobic ink, while the electrodes are deposited by screen-printing.
View Article and Find Full Text PDFHighly Sensitive Flow Cytometry Biosensor with a High Signal-to-Background Ratio for FEN1 Analysis via Solid-Phase Interface-Mediated Primer Exchange Reaction Amplification.
Anal Chem
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Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi, China.
Flap endonuclease 1 (FEN1) is a specific enzyme capable of recognizing and cleaving triplex DNA structures and releasing 5'-flap fragments. It plays a crucial role in the DNA metabolism of cells, participating in DNA replication and the repair of damaged DNA. Additionally, FEN1 is overexpressed in various tumor tissues, promoting tumor progression and drug resistance through different regulatory mechanisms.
View Article and Find Full Text PDFPharmacological Profiling of and : Unraveling the Antibacterial and Anti-Cancer Potential of Chemically Active Metabolites.
J Cancer
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Department of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University (PNU), P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Article Synopsis
- The study investigates the anti-cancer and anti-bacterial properties of medicinal plant extracts, focusing on two specific herbs, through various extraction methods.
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A triple protein-based ELISA for differential detection of ASFV antibodies.
Front Vet Sci
December 2024
College of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
African swine fever (ASF) caused by the ASF virus (ASFV) is a severe and highly contagious viral disease that poses a significant threat to the global pig industry. As no vaccines or effective drugs are available to aid prevention and control, early detection is crucial. The emergence of the low-virulence ASFV strain not expressing CD2v/MGFs (ASFVΔCD2v/ΔMGFs) has been identified domestically and internationally and has even become an epidemic in China, resulting in a complex epidemic.
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