AI Article Synopsis

  • This study aimed to identify factors affecting long-term metabolic control in youth with type 1 diabetes treated with insulin pumps.
  • Analysis of 113 patients showed that those with good baseline metabolic control maintained lower HbA1c levels over time, while those with poor control improved initially after pump initiation.
  • Key factors for better long-term outcomes included having good baseline control, a shorter time from diagnosis to pump therapy, and starting pump treatment at a younger age.

Article Abstract

Objective: This study was done to identify factors influencing long-term metabolic control in youth with type 1 diabetes mellitus (T1DM) treated with an insulin pump.

Research Design And Methods: Data were obtained from retrospective chart review of 113 patients (52 males) with T1DM treated with an insulin pump for up to 7 years. Their mean +/- SD age at diagnosis of T1DM was 9.7 +/- 5.1 years, and that at pump therapy initiation was 13.8 +/- 6.1 years. Linear trends and changes in hemoglobin A1c (HbA1c) levels following pump insertion were evaluated according to gender, metabolic control prior to initiation of pump therapy, time from diagnosis of diabetes until pump therapy, age at initiation, and the duration of pump treatment.

Results: Mean HbA1c levels of patients with good baseline metabolic control (HbA1c level 9%) control groups (8.1 +/- 0.9% and 8.2 +/- 1.1%, respectively; P < 0.001). However, with time a significant trend for increasing HbA1c level was demonstrated in the group with good metabolic control (P value for trend = 0.004). HbA1c levels of patients with poor baseline metabolic control decreased significantly immediately after pump initiation (9.4 +/- 1.6% vs. 8.0 +/- 1.2%, P = 0.0001) and thereafter remained stable (P value for trend = 0.54). In the multivariable analyses, baseline HbA1c level
Conclusions: Long-term response to pump treatment was dependent on baseline metabolic control. Early pump treatment had a significant long-term impact on metabolic control.

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Source
http://dx.doi.org/10.1089/dia.2010.0006DOI Listing

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