AI Article Synopsis
- MicroRNAs are small RNA molecules that play a key role in regulating gene expression and can also be found in the bloodstream, indicating their potential role in health and disease.
- The study focused on how levels of specific circulating microRNAs were altered in patients with stable coronary artery disease compared to healthy individuals, revealing significant reductions in several endothelial and inflammation-related microRNAs in the patients.
- The findings suggest that lower circulating levels of certain microRNAs, such as miR-126 and miR-155, may be associated with coronary artery disease, while levels of cardiac muscle-enriched microRNAs appear to be elevated.
Article Abstract
Rationale: MicroRNAs are small RNAs that control gene expression. Besides their cell intrinsic function, recent studies reported that microRNAs are released by cultured cells and can be detected in the blood.
Objective: To address the regulation of circulating microRNAs in patients with stable coronary artery disease.
Methods And Results: To determine the regulation of microRNAs, we performed a microRNA profile using RNA isolated from n=8 healthy volunteers and n=8 patients with stable coronary artery disease that received state-of-the-art pharmacological treatment. Interestingly, most of the highly expressed microRNAs that were lower in the blood of patients with coronary artery disease are known to be expressed in endothelial cells (eg, miR-126 and members of the miR-17 approximately 92 cluster). To prospectively confirm these data, we detected selected microRNAs in plasma of 36 patients with coronary artery disease and 17 healthy volunteers by quantitative PCR. Consistent with the data obtained by the profile, circulating levels of miR-126, miR-17, miR-92a, and the inflammation-associated miR-155 were significantly reduced in patients with coronary artery disease compared with healthy controls. Likewise, the smooth muscle-enriched miR-145 was significantly reduced. In contrast, cardiac muscle-enriched microRNAs (miR-133a, miR-208a) tend to be higher in patients with coronary artery disease. These results were validated in a second cohort of 31 patients with documented coronary artery disease and 14 controls.
Conclusions: Circulating levels of vascular and inflammation-associated microRNAs are significantly downregulated in patients with coronary artery disease.
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| http://dx.doi.org/10.1161/CIRCRESAHA.109.215566 | DOI Listing |
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