Department of Biomedical Engineering, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
Published: September 2010
AI Article Synopsis
Article Abstract
Polymeric nanoparticles were synthesized using both a photoinduced and base-catalyzed free radical polymerization method. These mild room temperature approaches allow sensitive molecules, such as dyes, to be encapsulated. Using this method, near infrared dye loaded nanoparticles for lymphatic migration and lymph nodes localization were synthesized. After injection into a large animal, we observed migration of the nanoparticles over 20 cm to the sentinel lymph. Nanoparticle migration was observed for nanoparticles of 50 nm but not 100 nm in diameter. These investigations further support the development of new materials and clinical approaches to treat cancer including identification of nodal disease, characterization of the extent of disease, and establishment of treatment regimes.
Currently, the increasing use of nickel metal-organic frameworks (Ni-MOF) and nickel oxide nanoparticles (NiO NPs) has raised concerns regarding their potential environmental impact on wastewater treatment systems. Herein, the responses of aerobic granular sludge (AGS) and algal-bacterial aerobic granular sludge (AB-AGS) to Ni-MOF and NiO NPs were investigated. The results showed that Ni-MOF concentrations of 50, 100, and 200 mg/L significantly reduced nutrient removal in both systems, particularly affecting ammonia, nitrite, and phosphorus removal, while denitrification processes remained stable.
Introduction: Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), a widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards a combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined with Chitosan-Au nanoparticles for chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted efficacy and minimizing side effects.
Cancer is a deadly disease with complex pathophysiological nature and is the leading cause of death worldwide. Traditional diagnosis methods often detect cancer at a considerably critical stage and the conventional methods of treatment like chemotherapy, radiation therapy, targeted therapy, and immunotherapy have several limitations, multidrug resistance, cytotoxicity, and lack of specificity are a few examples. These pose substantial challenge for effective and favourable cancer treatment.
A highly sensitive aptamer sensor (aptasensor) is proposed based on metal-organic frameworks-silver nanoparticles (AgNPs@MOF) to detect sulfadimethoxine (SDM) by surface-enhanced Raman spectroscopy (SERS). AgNPs@MOF with SERS activity was successfully fabricated by synthesizing AgNPs in situ on the surface of MIL-101(Fe), and SDM aptamer and Raman reporter 4-aminophenthiophenol (4-ATP) were selected as specific recognition elements and signal probes, respectively. When SDM was absent, the SDM aptamers were effectively adsorbed on the surface of AgNPs@MOF, thus keeping AgNPs@MOF in a dispersed state, resulting in a weakened SERS signal of 4-ATP.
