AI Article Synopsis
- The study investigated how leptin's role influences metabolic issues in schizophrenia patients treated with clozapine, focusing on genetic variations in leptin-related genes.
- The research comprised two phases: first, analyzing the metabolic profiles and genetic SNPs of 56 patients; second, assigning 52 of these patients to receive either metformin or placebo for 14 weeks.
- Results indicated that while certain triglyceride levels were lowest in one genetic group, metformin treatment led to increased glucose levels in one genotype and a decrease in metabolic indicators in another, revealing complex responses based on genetic variations.
Article Abstract
Background: The role of leptin in atypical antipsychotic-induced metabolic dysfunction was explored by assessing the anthropometric and metabolic profile and the response to metformin (MET) of clozapine- (CLZ) treated schizophrenia patients according to their single nucleotide polymorphisms (SNPs) in the leptin promoter (LEP2548/GA) and leptin receptor (LEPR Q223R) genes.
Methods: Phase 1. Body mass index (BMI), waist circumference, serum glucose, HbA1C, lipids, leptin, cortisol, insulin resistance index (HOMA-IR), metabolic syndrome and the frequencies of SNPs were assessed in 56 CLZ-treated patients (78.6% males). Phase 2. Fifty two phase 1 subjects were randomly assigned to MET XR (n=23) (1000 mg/day) or placebo (n=29) for 14 weeks. Changes in anthropometric and biochemical variables were compared between the SNPs.
Results: Phase 1. The QQ group displayed the lowest triglyceride levels (p<0.05). No other significant difference was observed. Phase 2. Change in anthropometric variables did not differ between the genotypes in any treatment group. After MET, glucose levels significantly increased in the GG group (p<0.05), whereas the HOMA-IR and the low density cholesterol significantly decreased in the QQ- but not in the (QR+RR) group (p<0.05). No differences were observed after placebo.
Conclusions: BW response to CLZ was not related to LEP- and LEPR-SNPs. The GG and (QR+RR) genotypes showed an unexpectedly opposite and blunted response to MET administration respectively.
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| http://dx.doi.org/10.1016/j.schres.2010.06.001 | DOI Listing |
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