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The Venom of : Proteomics, Neurotoxic Effect and Neutralization by Antivenom.
Vet Sci
November 2024
Department of Chemistry, Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobođenja 18, 11000 Belgrade, Serbia.
Deep proteomic analyses identified, in total, 159 master proteins (with 1% FDR and 2 unique peptides) from 26 protein families in the venom of Data are available via ProteomeXchange with the identifier PXD056495. The relative abundance of PLA2s is 11.60% of the crude venom, of which 4.
View Article and Find Full Text PDFClinicopathological biomarker patterns, venom detection and venom proteomics in canine Vipera berus envenomation.
Top Companion Anim Med
December 2024
Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ås, Norway.
Vipera berus (V. berus) bites are associated with high morbidity, including kidney injury, in dogs. Although antivenom is often used and perceived effective to treat this type of snakebite, it is costly and associated with adverse events and specific diagnostics for this type of snakebite are lacking.
View Article and Find Full Text PDFVipGrade electronic clinical tool: retrospective evaluation on a paediatric cohort of European viper bites.
Clin Toxicol (Phila)
November 2024
Paediatric Emergency Unit, Children's Hospital, Toulouse University Hospital Centre, Toulouse, France.
Introduction: The VipGrade is a French electronic clinical tool that was created in 2022 to help frontline clinicians grade envenomations due to European spp. and decide whether to use specific immunotherapy. The aim of this study was to test VipGrade on a paediatric retrospective cohort (2001-2022) of cases of spp.
View Article and Find Full Text PDFComparison of cytotoxicity methods for studying venom and the anticytotoxic potency of antivenom.
Cent Eur J Immunol
August 2024
Institute of Virology, Vaccines and Sera "Torlak", Belgrade, Serbia.
Introduction: Alternative in vitro tests that can be used instead of animal experiments are those that can most closely evaluate the biological activity of the drug of interest. For testing the potency of antivenom, these are the methods used to assess cytotoxicity. The aim of this study was to evaluate the most commonly used cytotoxicity methods for determining the protective potency of the antivenom Viekvin, which neutralizes Vipera ammodytes venom.
View Article and Find Full Text PDFTiny but Mighty: (Eastern Long-Nosed Viper) Ontogenetic Venom Variations in Procoagulant Potency and the Impact on Antivenom Efficacies.
Toxins (Basel)
September 2024
Adaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Article Synopsis
- The Eastern Long-Nosed Viper is one of Europe's most venomous snakes, and this study investigates how its venom varies from neonate (young) to adult stages, particularly in terms of procoagulant effects on human plasma.
- Findings show that neonate venom is more potent in activating blood-clotting factors compared to adult venom, challenging previous assumptions about venom effects based solely on adult specimens.
- Although all tested antivenoms can neutralize both venom types, they are generally more effective against adult venom, highlighting the need for further research on clinical implications of the observed venom variations.
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