AI Article Synopsis
- Quercetin is a dietary polyphenol that can have different effects on cells depending on its concentration, showing both cancer-preventative properties at low levels (1-40 microM) and pro-oxidant effects at higher levels (40-100 microM).
- Its antioxidant properties are key to its cancer-fighting capabilities, while higher concentrations lead to complex interactions with various biological pathways.
- The review highlights ongoing research into how quercetin's varying intake levels and concentrations may work together to impact cancer prevention and treatment.
Article Abstract
Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on cells depending on its concentration. Cancer preventative effects of quercetin are observed at concentrations of approximately 1-40 microM and are likely mediated by quercetin's antioxidant properties. Pro-oxidant effects are present at cellular concentrations of 40-100 microM. However, at higher concentrations, many novel pathways in addition to ROS contribute to its effects. The potent bioactivity of quercetin has led to vigorous study of this compound and revealed numerous pathways that could interact synergistically to prevent or treat cancer. The effect of intake and concentration on emerging pathways and how they may interact are discussed in this review.
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| http://dx.doi.org/10.1111/j.1753-4887.2010.00301.x | DOI Listing |
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