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Current vaccines, experimental immunization trials, and new perspectives to control selected vector borne blood parasites of veterinary importance.
Front Vet Sci
November 2024
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Article Synopsis
- * Symptoms of these infections range from fever and jaundice to neurological disorders, with varying mortality rates, necessitating effective control measures.
- * Current research is focused on developing new vaccines, with promising approaches including recombinant antigens and genetically modified parasites, despite existing challenges like practicality and concerns about traditional vaccine methods.
Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and Efficacy.
ACS Infect Dis
December 2024
Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
The proteasome is essential for eukaryotic cell proteostasis, and inhibitors of the 20S proteasome are progressing preclinically and clinically as antiparasitics. We screened, the causative agent of human and animal African trypanosomiasis, with a set of 27 carmaphycin B analogs, irreversible epoxyketone inhibitors that were originally developed to inhibit the20S (Pf20S). The structure-activity relationship was distinct from that of the human c20S antitarget by the acceptance of d-amino acids at the P3 position of the peptidyl backbone to yield compounds with greatly decreased toxicity to human cells.
View Article and Find Full Text PDFInsights into trypanosomiasis transmission: Age, infection rates, and bloodmeal analysis of Glossina fuscipes fuscipes in N.W. Uganda.
PLoS Negl Trop Dis
October 2024
Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: Tsetse flies (Glossina) transmit species of Trypanosoma which cause human African trypanosomiasis (HAT) and animal African trypanosomiasis (AAT). Understanding the epidemiology of this disease and controlling the vector rationally requires analysis of the abundance, age structure, infection rates and feeding patterns of tsetse populations.
Methods: We analysed a population of G.
From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection.
FEBS J
October 2024
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Adipose tissue is a rich source of diverse cell populations, including immune cells, adipocytes and stromal cells. Interactions between these different cell types are now appreciated to be critical for maintaining tissue structure and function, by governing processes such as adipogenesis, lipolysis and differentiation of white to beige adipocytes. Interactions between these cells also drive inflammation in obesity, leading to an expansion of adipose tissue immune cells, and the secretion of proinflammatory cytokines from immune cells and from adipocytes themselves.
View Article and Find Full Text PDFInvestigation of Novel Isatinylhydantoin Derivatives as Potential Anti-Kinetoplastid Agents.
ChemMedChem
January 2025
Centre of Excellence for Pharmaceutical Sciences (Pharmacen), Faculty of Health Sciences, North-West University, 11 Hoffmann Street, Potchefstroom, 2520, South Africa.
Neglected tropical diseases are a group of infectious diseases with a high endemicity in developing countries of Africa, Asia, and the Americas. Treatment for these diseases depends solely on chemotherapy, which is associated with severe side effects, toxicity, and the development of parasitic resistance. This highlights a critical need to develop new and effective drugs to curb these diseases.
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