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A high circulating copy number of HHV-6 due to chromosomal integration in a child with acute lymphoblastic leukemia. | LitMetric
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A high circulating copy number of HHV-6 due to chromosomal integration in a child with acute lymphoblastic leukemia.

Olli Lohi Mikko Arola Irmeli Lautenschlager Elisabeth P Nacheva Kim Vettenranta

Pediatr Blood Cancer

Pediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland.

Published: December 2010

We report a case of a 3.5-year-old female with a very high copy number of human herpesvirus 6 (HHV-6) detected by PCR in blood during acute lymphoblastic leukemia induction therapy. The patient was unsuccessfully treated with antiviral drugs. HHV-6 genome was shown to be constitutively integrated into chromosome 22q-tel, likely to be inherited from the mother who was found to carry high HHV-6 copy number. This case highlights the importance of excluding HHV-6 chromosomal integration before diagnosing HHV-6 infection or reactivation in immunocompromised patients.

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 Source
http://dx.doi.org/10.1002/pbc.22671DOI Listing

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