We present a detailed experimental study on the influence of dispersion on the pulse formation in passively modelocked vertical-external-cavity surface-emitting lasers (VECSELs). We have demonstrated that the shortest pulse duration requires slightly positive dispersion to balance the nonlinear phase shift induced by strong semiconductor gain and absorber saturation. This is in contrast to soliton modelocking in ion-doped solid-state lasers - but similarities remain and will be discussed. Our results are in good qualitative agreement with numerical simulations and confirm the quasi-soliton modelocking mechanism of ultrafast VECSELs.
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http://dx.doi.org/10.1364/OE.18.010143 | DOI Listing |
ACS Omega
January 2025
Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou 350000, China.
The impact of changes in peripheral blood mononuclear cells (PBMCs) on the prognosis of patients with cardiogenic shock (CS) receiving venous-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. A single-cell RNA-sequencing (scRNA-seq) and a bulk RNA-sequencing (bulk RNA-seq) data sets of pre-ECMO PBMCs of CS patients were obtained from the gene expression omnibus database, which were analyzed using the "Seurat" and "limma" packages, respectively. The counts of different PMBC cell types, differential expression genes (DEGs), pathway enrichment analysis, cell-cell communication analysis, pseudotime analysis, and immune cell infiltration analysis were compared between VA-ECMO groups with different prognoses.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Department of Chemical and Pharmaceutical Engineering, Faculty of Chemistry and Pharmacy, University of Sofia, Bulgaria.
Hypothesis: Solubilization is a fundamental process that underpins various technologies in the pharmaceutical and chemical industry. However, knowledge of the location, orientation and interactions of solubilized molecules in the micelles is still limited. We expect all-atom molecular dynamics simulations to improve the molecular-level understanding of solubilization and to enable its in silico prediction.
View Article and Find Full Text PDFFish Shellfish Immunol
January 2025
Department of Biological Sciences, Kongju National University, Gongju 32588, South Korea. Electronic address:
Single-cycle viruses hold great promise as fish viral vaccines due to their high protective efficacy. Although the efficacy of the vaccine in olive flounder and rainbow trout has been proven through previous research, safety must be additionally proven considering the environment of use for commercialization. This study comprehensively assesses the safety of rVHSV-GΔTM and its impact on both the host and the surrounding environment, including the coastal habitat of nearby species and seawater.
View Article and Find Full Text PDFPLoS One
January 2025
Intensive Care Unit, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, PR China.
Background: Shenfu injection (SFI), derived from a traditional Chinese medicine (TCM) prescription, is an effective drug for the treatment of sepsis-induced myocardial injury (SIMI) with good efficacy, but its exact therapeutic mechanism remains unclear.
Methods: SwissTargetPrediction and GeneCards database were used to obtain relevant targets for SFI and SIMI. STRING 11.
Sci China Life Sci
January 2025
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Adipogenesis is the healthy expansion of white adipose tissue (WAT), serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the body. Therefore, the identification of novel regulatory molecules in adipogenesis, specifically membrane receptors such as G protein-coupled receptors (GPCRs), holds significant clinical promise. These receptors can serve as viable targets for pharmaceuticals, offering potential for restoring metabolic homeostasis in individuals with obesity.
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