The paper discusses the principles of therapy to prevent and correct chronic fetal hypoxia in late gestosis and provides evidence for the rationale of antioxidant therapy. Primary emphasis is laid on the results of the multimodality therapy for late gestosis and associated chronic fetal hypoxia, which was supplemented with essentiale. A follow-up of 549 pregnant females with Grades I, II, and III nephropathy, 153 of whom were receiving essentiale, as well as fetuses and neonates suggests that it is justifiable to apply antioxidative agents to the treatment of late gestosis and associated fetal hypoxia.
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