Cancer continues to be a major cause of mortality despite decades of effort and expense. The problem reviewed here is that before many cancers are discovered they have already progressed to become drug resistant or metastatic. Biomarkers found in blood or other body fluids could supplement current clinical indicators to permit earlier detection and thereby reduce cancer mortality.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-0987 | DOI Listing |
Biotechnol Appl Biochem
December 2024
Department of Basic Sciences, University of Erciyes, Kayseri, Turkey.
Enhancing the biocompatibility of biomaterials is a critical aspect of tissue engineering and regenerative medicine. Advances in 3D bioprinting technology, blending natural and synthetic materials for the production of bioink, offer new opportunities to develop highly biocompatible materials that can closely mimic the native tissue environment. In this study, we used pericardial fluid structure (PFS)-based material together with alginate to mimic the extracellular matrix (ECM) and produce a bioink material.
View Article and Find Full Text PDFAdv Mater
November 2024
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Laboratory of Flexible Electronics Technology, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, P. R. China.
Engineered hydrogel patches have shown promising therapeutic effects in the treatment of myocardial infarction (MI), especially anisotropic patches that mimic the characteristics of native myocardium have attracted widespread attention. However, it remains a great challenge to develop cardiac patches with long-range and orderly electrical conduction based on an effective, mild, and rapid strategy. Here, a multifunctional anisotropic cardiac patch is presented based on microfluidic manipulation.
View Article and Find Full Text PDFJ Integr Neurosci
June 2024
Area of Pharmacology and Nutrition and Bromatology, Department of Basic Health Sciences, School of Health Sciences, Universidad Rey Juan Carlos, High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Associated Unit R+D+i Institute of Medicinal Chemistry (IQM-CSIC)-URJC, 28922 Alcorcón, Spain.
Gels
May 2024
School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266555, China.
Considering the damage caused by conventional fracturing fluid in low-permeability reservoirs, a novel fracturing fluid (FNG) combining hydroxypropyl guar (HPG) and functionally modified nano-silica (FMNS) was prepared. The properties of heat/shear resistance, rheological property, proppant transportation, and formation damage were evaluated with systematic experiments. The results showed that the viscosities of FNG before and after the heat/resistance were 1323 mPa·s and 463 mPa·s, respectively, while that of conventional HPG gel was 350 mPa·s.
View Article and Find Full Text PDFClin Exp Metastasis
August 2024
Institute of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
The concept of liquid biopsy analysis has been established more than a decade ago. Since the establishment of the term, tremendous advances have been achieved and plenty of methods as well as analytes have been investigated in basic research as well in clinical trials. Liquid biopsy refers to a body fluid-based biopsy that is minimal-invasive, and most importantly, allows dense monitoring of tumor responses by sequential blood sampling.
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