The gelatin plasma substitute is often polydisperse and heterogenous, making it difficult to determine the elimination rate and half-life in the body. In this study, one method was developed based on quantitative determination of hydroxyproline derivatives. Two plasma substitutes were prepared by succinylation and genipin-crosslinking, respectively. After transfusion, the blood samples were hydrolyzed and derivatized, and then analyzed by HPLC. A two-phase exponential association equation was used for fitting the time-concentration curves. The results indicated that this method could be used for quantitative determination of gelatin in blood, and the pharmacokinetic parameters such as elimination rate and half-life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/10731199.2010.494582 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization of Biopolymer Hydrogels Prepared with Water Exposed to Indirect Plasma Treatment.
Int J Mol Sci
December 2024
Department of Functional Food Products Development, The Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37/41, 51-630 Wroclaw, Poland.
This study aimed to evaluate the influence of indirect-plasma-treated water (IPTW) in the preparation of hydrogels. Three commonly used natural, biodegradable polymers with the ability to form gels were selected: gelatin, carrageenan, and sodium alginate. The pH, gelling temperature, texture profile, swelling degree, and color of hydrogels were evaluated, and the polymers were subjected to Fourier-transform infrared (FTIR) spectroscopy.
View Article and Find Full Text PDFInsight into formation and structure of wheat starch-lauric acid complexes by extrusion: Effect of plasma-activated water.
Food Chem
December 2024
College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450000, PR China. Electronic address:
The objective of this study is to examine how plasma-activated water (PAW) affects the formation of complexes between wheat starch (WS) and lauric acid (LA) during extrusion. The findings from various analysis, including complexing index, X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, and differential scanning calorimetry, revealed that PAW promoted the formation of WS-LA complexes during extrusion, resulting in a better long-range and short-range ordered structure, as well as higher gelatinization enthalpy. Consequently, PAW led to lower solubility, swelling power, gel property, and rapidly digestible starch content but higher resistant starch content.
View Article and Find Full Text PDFThe gelatin sponge loaded with curcumin coating exhibits a synergistic effect of hemostasis, anti-inflammatory, and anti-scarring.
Biomater Adv
December 2024
International Chinese-Belorussian Scientific laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei street, Nanjing 210094, China. Electronic address:
Postoperative wound healing has been extensively studied and well-documented. Gelatin sponges are commonly used in surgeries for blood absorption. If these sponges can also release drugs with anti-scarring and anti-inflammatory effects, they would significantly enhance wound healing.
View Article and Find Full Text PDFMacrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.
Biomaterials
May 2025
Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Paclitaxel (PTX), typically administered intravenously (IV) as chemotherapy, shows promise for triggering immunogenic cell death (ICD) and may serve as a potential immunotherapy. This study introduces an oral PTX delivery method using an enteric-coated gelatin capsule containing capric acid oil and an effervescent agent, optionally with decylamine-conjugated β-glucans (DA-βGlus).
View Article and Find Full Text PDFNeurotensin Conjugated Polymeric Porous Microparticles Suppress Inflammation and Improve Angiogenesis Aiding in Diabetic Wound Healing.
Macromol Biosci
November 2024
Department of Pharmacy, Birla Institute of Technology and Science (BITS PILANI), Pilani, Rajasthan, 333031, India.
Neurotensin (NT), a bioactive tridecapeptide aids in diabetic wound healing by modulating inflammation and angiogenesis. However, its rapid degradation in peptidase-rich wound environment (plasma half-life <2 min) limits its efficacy. To address this, neurotensin-conjugated polymeric porous microparticles (NT-PMP) were developed and loaded in gelatin (hydrogel 15% w/v) for topical application, enabling sustained NT release to enhance therapeutic outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!